Depiction of the cLPP and CIP methods. cLPP captures both strands of the targeted genomic DNA, generating two complementary single-stranded DNA circles. Each of the strands is then sequenced in the forward and reverse direction to yield four unique reads. CIP captures only one strand of the target genomic DNA region and generates a single-stranded DNA circle. The target region is then enriched by PCR and sequencing performed.