Genes in the microglial module are related to early NFT pathology. The top 250 gene-gene interactions of the light green module are displayed as measured by topological overlap. Larger dots represent hub genes with at least 15 connections. Circled genes are significantly up-regulated in NFT-bearing neurons (P < 0.03) and also overexpressed in Braak stage 2 controls (P < 0.03). The length of each line and the position of each node were arbitrarily chosen by VisANT to highlight network structure. The top 25 genes based on module membership are also presented.