Table 3 Top genes differentially expressed by disease and region
From: Genes and pathways underlying regional and cell type changes in Alzheimer's disease
| Gene | Fold change | P-value |
|---|---|---|
| Genes regionally DE in control only | ||
| CA1-specific | ||
| SPARCL1 | -1.44 (-1.42) | 7.0E-08 |
| CYP1B1 | -1.42 | 4.7E-07 |
| PPP1R16B | -1.49 | 4.2E-06 |
| KCNH3 | -2.07 | 5.2E-06 |
| EPHB1 | -1.47 | 5.8E-06 |
| STOX1 | -1.56 | 5.8E-06 |
| MT1M | -1.58 | 1.1E-05 |
| ID2 | -1.49 | 1.4E-05 |
| SOX2 | -1.49 | 1.7E-05 |
| GPAM | -1.53 | 1.9E-05 |
| CA3-specific | ||
| NRIP3 | 2.14 (2.52) | 7.4E-08 |
| ABHD12 | 1.54 (1.60) | 9.0E-07 |
| TMEM158 | 1.72 | 2.0E-06 |
| TSPAN18 | 4.00 (4.07) | 2.9E-06 |
| TOMM34 | 1.85 | 4.2E-06 |
| CCDC109A | 1.52 | 6.7E-06 |
| HOMER2 | 1.57 | 6.8E-06 |
| CPNE4 | 3.18 | 7.5E-06 |
| LINGO1 | 1.65 | 7.8E-06 |
| HMGCR | 1.65 | 8.8E-06 |
| Genes changing with AD in CA1 only | ||
| Down with AD | ||
| SEPT5 | -1.59 | 2.8E-05 |
| CSPG5 | -1.82 | 6.9E-05 |
| WFDC1 | -1.47 | 8.2E-05 |
| KCNIP1 | -1.77 | 1.0E-04 |
| CXCL14 | -1.96 (-2.09) | 1.1E-04 |
| ANKRD20A1 | -1.81 | 1.6E-04 |
| SEC14L5 | -1.43 (-1.25) | 3.0E-04 |
| LOC648639 | -1.71 | 3.1E-04 |
| ARPP-21 | -1.92 | 3.9E-04 |
| ADRA1B | -2.11 | 6.3E-04 |
| Up with AD | ||
| S100A6 | 1.59 (1.83) | 4.6E-07 |
| GEM | 1.64 (2.05) | 5.9E-06 |
| PFKFB3 | 1.44 | 4.5E-05 |
| SERPINA3 | 2.11 | 6.7E-05 |
| TPST1 | 1.63 | 1.5E-04 |
| SPARC | 1.71 | 1.6E-04 |
| CAB39L | 1.46 | 1.9E-04 |
| RCN1 | 1.42 | 2.0E-04 |
| DMN | 1.73 | 2.9E-04 |
| BCL2 | 1.45 | 3.1E-04 |