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Figure 4 | Genome Medicine

Figure 4

From: Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors

Figure 4

Validation of copy number changes by Infinium CNA profiling across all samples. (A) Forty-eight of 50 (96%) copy number alterations detected by sequencing were confirmed (green: confirmed, pink: not confirmed, grey: no data); (B) Genetic changes in 'P17_neg' detected by NGS (extracted from Figure 2); (C) Illustration of copy number changes (obtained from Infinium CNA Profiling) in 'P17_neg'. Both the loss of the CDKN2A and CDKN2B genes (in a region of loss within chromosome 9) and the gain of the CCND1 gene (in an amplified region of chromosome 11) are shown. Y-axis: log fold change of copy number, X-axis: copy number changes across all chromosomes.

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Genome Medicine

ISSN: 1756-994X

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