Figure 1

Obesity-susceptibility loci discovered through genome-wide association studies (GWAS) for body mass index (blue), three waves of GWAS for waist circumference and waist-to-hip ratio (pink) and two waves of GWAS for extreme and early onset of obesity (green). Each Venn diagram represents the loci from one paper, except for papers that discovered only one locus, that is, the fat mass and obesity associated gene FTO [14, 15, 33] and the near-MC4R loci [16, 36], for which no Venn diagram was drawn. An additional three BMI-associated loci (TOMM40-APOE-APOC1, SREBF2, and NTRK2) were identified using the gene-centric ITMAT-Broad-Candidate Gene Association Resource (IBC) array [21]; these are not depicted. Figure modified and updated from Loos [11].