Table 1 Overview of subject characteristics (n = 50)

Age group at screening, years

   50-59

   60-69

   70-79

Ethnicity

   White

   Black

   Hispanic

Hormone replacement therapy use

   Never used

   Past user

   Current user

Hormone replacement therapy duration, years

   <5

   5 to <10

   10+

Body mass index (BMI), kg/m²

   <25

   25 to <30

   ≥30

BMI at year 1

   <25

   25 to <30

   ≥30

Smoking

   Never smoked

   Past smoker

   Current smoker

Parity

   Never pregnant/no term pregnancy

   ≥1 term pregnancy

Age at first birth, years

   <20

   20-29

   30+

Age at hysterectomy, years

   <40

   40-49

   50-54

   55+

Prior bilateral oophorectomy

   No

   Yes

Treated diabetes

   No

   Yes

Treated for hypertension or blood pressure ≥140/90 mmHg

   No

   Yes

History of high cholesterol requiring pills

   No

   Yes

Statin use at baseline

   No

   Yes

Aspirin (≥80 mg) use at baseline

   No

   Yes

History of myocardial infarction

   No

History of angina

   No

   Yes

History of coronary artery bypass graft/percutaneous transluminal coronary angioplasty

   No

History of stroke

   No

History of deep vein thrombosis or pulmonary embolism

   No

Family history of breast cancer (female)

   No

   Yes

History of fracture on/after age 55

   No

   Yes

Gail Model five year risk of breast cancer

   <1

   1 to <2

   2 to <5

Number of falls in last 12 months

   None

   1

   2