Cross-species integration. (a) Precision recall within the tissue training dataset for the pathprint (red indicates mean average precision (MAP) = 0.90), unthresholded POE (dashed; MAP =, 0.88), random gene sets (black, MAP = 0.83), Gene Expression Barcode (blue, MAP = 0.73), Spearman gene expression correlation (green, MAP = 0.71). (b) Comparison of distance metrics; precision-recall curves for aggregated mouse to human tissue data based on a thresholded pathprint build produced using Euclidean (blue), Manhattan (green), and Mahalanobis (red) distances. (a,b) Tissue-dominated versus platform/species-dominated clustering showing plots of the two most significant principal components (PCs) for (c) the pathprint and (d) the Gene Expression Barcode (red, brain; yellow, kidney; green, liver; light blue, lung; dark blue, muscle; pink, spleen; circles, Mouse 430A2; diamonds, Human 133plus2; crosses Human 133A). (e) Functional classification of tissues and blood cell types. Hierarchical clustering of consensus pathprints for human and mouse tissues on three platforms based on the Wikipathway and Reactome pathways that significantly contributed to clustering. Colors indicate scores: red, 1; white, 0; and blue, -1).