Clinically important self renewal-associated signature (SRAS) in acute myeloid leukemia (AML). (a) Pathways differentially expressed in stem and non-stem cell profiles in leukemic and normal samples were found in human and mouse experiments. Four common SRAS pathways were identified. (b) The SRAS pathprint scores of patients with AML were significantly associated with survival. (c) A single pathway of interest is highlighted, the overall PGCL2 (α 2u globulin) module is upregulated in normal and cancer stem cells but individual genes differ between species. This pathway is strongly associated with survival (see Additional file 13).