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Figure 1 | Genome Medicine

Figure 1

From: Single cell expression quantitative trait loci and complex traits

Figure 1

Distribution of single-cell quantitative trait loci detected at basal and perturbed states in HapMap lymphoblastoid cell lines derived from 15 unrelated individuals reported in[7]. The relative number of single-cell quantitative trait loci reported in Supplementary Table 1 from [7] is represented as a doughnut chart. Several different phenotypes derived from single-cell transcriptomic analysis were modeled as described in [7], and tested for association with single nucleotide polymorphisms within 50 kb of the gene. Beyond signals coming from cells with undetected expression (grey), a substantial number of single-cell quantitative trait loci associated with single-cell transcriptional variation due to cell cycle, gene burst, gene-gene correlation, network connectivity and expression noise were detected. The highlighted sector (black) denotes the relatively small contribution of whole-tissue expression quantitative trait loci, which were obtained using gene expression levels averaged over many cells.

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