Figure 1

Change in AUC, NRI(>0.01) and IDI per different values of the baseline AUC when rare genetic variants were added to prediction baseline model. ΔAUC, change in AUC between the model with and without the rare genetic variants; AUC, area under the receiver operating characteristic curve; IDI, integrated discrimination improvement; n, number of common variants added; NRI, net reclassification improvement; OR, odds ratio; p, frequency of the risk allele; AUC 1, AUC of the baseline model. Disease risk is 4%. Population size is 200,000. Results are median values from 10 simulations.