Box plots of gene expression changes after treatment of cultures of human hepatocytes with drugs labeled as no-, less- or most-DILI-concern. (A) Serum amyloid. (B) Sulfide quinone oxidoreductase. (C) Apolipoprotein C2. (D) Ceruloplasmin. Box blots marked with a star are statistically significant at P < 0.05. Cultures of human hepatocytes were treated with drugs labeled as either no- (n = 8), low- (n = 45) or most-DILI-concern (n = 39) for 2 and 24 h, respectively. A full list of drugs used is given in Additional file 6.