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Figure 1 | Genome Medicine

Figure 1

From: Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callers

Figure 1

Sensitivity as a function of mutation allele frequency for five sSNV-detecting tools. Given an allele frequency value f, the sensitivity of a tool T (either JointSNVMix, MuTect, SomaticSniper, Strelka, or VarScan 2) is calculated as: S T = N T /N f where N f is the total number of sSNVs with sequencing depth ≥8, the number of alternate allele-supporting reads ≥2 in the disease sample, and an allele frequency less than f, and N T is the number of sSNVs that the tool T identified out of these N f point mutations.

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