Table 3 Number of validated true/false sSNVs detected using the five tools in the lung cancer samples
From: Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callers
Tool | Lung tumors (n = 18) |  | Lung cancer cell lines (n = 7) |  | Totala |  |  | ||
|---|---|---|---|---|---|---|---|---|---|
TP | FP | TP | FP | TP | FP | ||||
# High quality | # Low quality | # High quality | # Low quality | # High quality | # Low quality | ||||
JointSNVMix | 30 | 17 | 6 | 49 | 0 | 11 | 79 | 17 | 17 |
MuTect | 30 | 19 | 11 | 47 | 0 | 7 | 77 | 19 | 18 |
SomaticSniper | 33 | 17 | 10 | 47 | 0 | 9 | 80 | 17 | 19 |
Strelka | 27 | 17 | 8 | 51 | 0 | 10 | 78 | 17 | 18 |
Varscan 2 | 35 | 8 | 5 | 51 | 0 | 13 | 86 | 8 | 18 |