Table 1 Proteins unchanged at P1 but increased >50% or 20 to 50% at P5 in the rostral band of LAL muscle from SMA mice compared with littermate controls
Gene name | Protein name | Accession number | Peptides at P5 | Ratio KO/control P1 | Ratio KO/control at P5 | Score at P5 | Anova ( P-value) at P5 |
|---|---|---|---|---|---|---|---|
G6pI | Glucose-6-phosphate isomerase | G6PI_MOUSE | 6 | 1.03 | 1.98 | 245.68 | 6.92E-06 |
Grp75 | Stress-70 protein | GRP75_MOUSE | 3 | 1.02 | 1.82 | 170.83 | 5.59E-04 |
Tbb5 | Tubulin beta-5 chain | TBB5_MOUSE | 2 | 1.02 | 1.80 | 639.05 | 3.69E-05 |
Plec1 | Plectin-1 | PLEC1_MOUSE | 21 | 1.18 | 1.63 | 879.72 | 4.67E-06 |
Thil | Acetyl-CoA acetyltransferase | THIL_MOUSE | 7 | 1.09 | 1.59 | 448.39 | 2.95E-04 |
Calr | Calreticulin | CALR_MOUSE | 3 | 1.12 | 1.51 | 83.76 | 2.08E-03 |
Aatm | Aspartate aminotransferase | AATM_MOUSE | 7 | 1.17 | 1.50 | 443.54 | 1.50E-04 |
Thim | 3-Ketoacyl-CoA thiolase | THIM_MOUSE | 12 | 1.02 | 1.41 | 473.14 | 1.16E-03 |
Anxa2 | Annexin A2 | ANXA2_MOUSE | 10 | 1.04 | 1.33 | 729.11 | 1.28E-03 |
Pura1 | Adenylosuccinate synthetase isozyme 1 | PURA1_MOUSE | 5 | 1.09 | 1.30 | 247.24 | 1.19E-03 |
S10ab | Protein S100-A11 | S10AB_MOUSE | 2 | 1.01 | 1.25 | 166.21 | 2.78E-02 |
Hbb2 | Hemoglobin subunit beta-2 | HBB2_MOUSE | 6 | 1.01 | 1.23 | 702.27 | 1.51E-03 |
Lmna | Lamin-A/C | LMNA_MOUSE | 7 | 1.16 | 1.21 | 567.31 | 2.19E-04 |
Vime | Vimentin | VIME_MOUSE | 12 | 1.17 | 1.21 | 776.2 | 3.50E-04 |