Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

Table 2 Proteins unchanged at P1 but decreased >50% or 20 to 50% at P5 in the rostral band of LAL muscle from SMA mice compared with littermate controls

Gene name	Protein name	Accession number	Peptides at P5	Ratio KO/control at P1	Ratio KO/control at P5	Score at P5	Anova ( P-value) at P5
Rrbp1	Ribosome-binding protein 1	RRBP1_MOUSE	3	0.89	0.15	60.23	1.97E-05
Tpm1	Tropomyosin alpha-1 chain	TPM1_MOUSE	6	0.92	0.25	652.67	6.87E-06
Actn2	Alpha-actinin-2	ACTN2_MOUSE	15	0.89	0.61	1413.57	1.82E-04
Tcpb	T-complex protein 1 subunit beta	TCPB_MOUSE	3	0.89	0.66	162.09	2.07E-03
Postn	Periostin	POSTN_MOUSE	3	0.99	0.70	142.66	7.55E-04
Hs90a	Heat shock protein HSP 90-alpha	HS90A_MOUSE	3	0.99	0.70	326.05	7.71E-04
Hs90b	Heat shock protein HSP 90-beta	HS90B_MOUSE	8	0.90	0.70	600.51	6.45E-05
Rtn4	Reticulon-4	RTN4_MOUSE	5	0.86	0.79	123.82	1.69E-02
Nb5r3	NADH-cytochrome b5 reductase 3	NB5R3_MOUSE	3	0.95	0.79	65.43	3.90E-05

ISSN: 1756-994X