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Figure 2 | Genome Medicine

Figure 2

From: Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy

Figure 2

Comparison of correlated and directionally opposed birth and age differentially methylated probes (DMPs). (A) Multi-dimensional scaling (MDS) and (B) heatmap plots of 300 directionally correlated birth DMPs. Mean group β-values of correlated DMPs that (C) increased (159 probes) or (D) decreased (141 probes) with age. (E) MDS and (F) heatmap plots of 431 directionally opposed age and birth DMPs. Mean group β-values of directionally opposed DMPs that were (G) higher (314 probes) or (H) lower (117 probes) in term birth samples. The sample groups are color coded as follows: term birth, blue; preterm birth, black; term birth at 18 years, green; preterm at 18 years, red. Birth DMPs and age DMPs (defined using term group only) were analyzed by sub-setting probes that had changed in the same (correlated) or differing directions (opposing).

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