Figure 3
Genomic and sequence context of differentially methylated probes (DMPs). Enrichment or depletion of DMPs displayed as the log10 of the observed/expected frequencies for each category with significance from hypergeometric test results displayed as *P < 10-5, **P < 10-10, and ***P < 10-20. (A) Genomic enrichment distribution of 1,555 birth DMPs (black) and 3,244 age DMPs (white) showed similar profiles. (B) Top 1,500 probes ranked by odds of differential methylation at 18 years (18-year DMPs; dark grey) and the top 1,500 most variable methylated probes (18-year VMPs; light grey) showed distinct enrichment profiles, with the 18-year DMPs showing the opposite enrichment to the birth DMPs and age DMPs.