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Figure 1 | Genome Medicine

Figure 1

From: Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications

Figure 1

Schematic representation of linear and branched evolution patterns. The linear evolution model implies that each new subclone carries forward all the pre-existing mutations, whereas the branched evolution model implies that subclones expand independently and acquire different mutations over time. In this schematic representation, mutations are indicated by colors, with the previous mutations indicated in small squares within the new cell.

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