Figure 3
The outlying degree is more robust to variability across samples than the Zscore in experimental data. (A) The top five genes for both the Zscore and outlying degree method were found for sample 09206. From comparison purposes we plotted the distribution of the expression levels of the 12 patient samples for the top five ranked genes in either method. It was clear that the Zscore ranked higher those genes where a single outlier was found with the remainder of the samples tightly grouped together whereas the outlying degree (k = 6) ranked higher those genes with large differences while tolerating more expression variability between the samples. Exon-level summary of the genes ranked the highest in (A) (Rank 1) are shown for both (B) the Zscore and (C) the outlying degree methods.