The pattern of LD in the European HGDP samples on chromosome 9:22071397-22124172, a region approximately 53 kb long. R2 values between each SNP pair are shown in shades of grey (black R2 = 1, white R2 = 0) and within each box. The CHD and T2D LD regions in Europeans are clearly separate. The SNPs best tagging the disease-associating haplotypes (rs4977574 and rs10811661) are in bold-face. The positions of two SNPs that have been identified as most strongly associated with CHD in two separate fine-mapping studies of Europeans, rs2891168 and rs10757278 (see text), are shown above the genomic sequence line. The position of the ANRIL gene is shown at the top, while the CDKN2B gene is located 72 kb upstream of the first SNP shown, rs10116277.