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Table 2 The frequencies of estimated haplotypes† for eight CHD-associated SNPs in seven different geographic regions

From: Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease

rs10116277 rs1537370 rs10738607 rs4977574 rs944797 rs2383207 rs1537375 rs1333049 Africa N = 102 Middle East N = 160 Europe N = 156 C.S. Asia N = 200 E. Asia N = 229 Oceania N = 28 America N = 63
G C T A A A T G NF 0.209 0.384 0.327 0.328 0.554 0.449
T T C G* G* G* C* C 0.115 0.516 0.536 0.478 0.470 0.161 0.302
T T C G* G* G* C* G NF 0.100 0.031 0.029 NF 0.143 NF
G C C G* G* G* C* C NF 0.021 0.017 NF 0.019 NF 0.032
T T C A G G C G 0.021 0.019 NF NF NF NF NF
T T T A A G C G 0.345 0.041 NF NF NF 0.054 NF
T C T A A G C G 0.246 0.013 NF NF NF NF 0.016
T T C A A G C G NF NF NF 0,035 0.092 0.054 NF
T T T A G G T G 0.129 0.031 NF 0,027 NF NF NF
G C T A G G C C NF NF NF NF NF NF 0.147
G C T A A G C G 0.027 NF NF NF NF 0.036 NF
T T T A A A T G NF 0.019 NF 0,015 0.039 NF 0.012
G C T A A A T C NF NF NF 0,013 NF NF 0.016
  1. The risk alleles in Europeans are in bold-face and italicized, and the core risk haplotype is marked with an asterisk. †Population-specific haplotypes <5% frequent were omitted. NF, haplotype not found in given geographic region.
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Genome Medicine

ISSN: 1756-994X

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