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Figure 1 | Genome Medicine

Figure 1

From: MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications

Figure 1

let-7 is a potent tumor suppressor microRNA. The let-7 microRNA (miRNA) can affect several key cellular pathways (such as those involved in the cell cycle, cell growth, cell proliferation, migration or invasion) by targeting key effector genes. In cancer, the function of let-7 is often lost or impaired through chromosomal deletions, mutations in the target sequence of regulated mRNAs, mutations in the seed site of the miRNA, or through post-transcriptional regulation by proteins such as LIN-28, whose expression is driven by potent oncogenes such as MYC and nuclear factor (NF)-κB.

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