CHD | ||||||||
---|---|---|---|---|---|---|---|---|
 | E + P | E-alone | Difference between cohortsb | Overall case vs. control differencec | ||||
 | Cases | Controls | P valuea | Cases | Controls | P valuea | ||
N | 206 | 202 | Â | 152 | 150 | Â | Â | Â |
B2M (mg/mL) | N = 206, 141d | N = 202, 138d |  | N = 152, 110d | N = 150, 108d |  |  |  |
Baseline | 0.13 (0.06, 0.29) | 0.11 (0.06, 0.22) | <.001 | 0.13 (0.06, 0.32) | 0.12 (0.05, 0.27) | 0.05 | 0.44 | 0.0001 |
Year 1 | 0.15 (0.07, 0.31) | 0.13 (0.06, 0.27) | 0.01 | 0.15 (0.06, 0.38) | 0.14 (0.07, 0.30) | 0.04 | 0.87 | 0.003 |
Change | 1.04 (0.51, 2.11) | 1.03 (0.55, 1.94) | 0.68 | 1.02 (0.48, 2.17) | 1.00 (0.60, 1.67) | 0.18 | 0.69 | 0.67 |
ORM1 (mg/mL) | N = 204, 139 | N = 202, 138 |  | N = 133, 96 | N = 150, 108 |  |  |  |
Baseline | 0.52 (0.27, 1.02) | 0.49 (0.27, 0.91) | 0.10 | 0.52 (0.25, 1.08) | 0.51 (0.25, 1.02) | 0.61 | 0.52 | 0.16 |
Year 1 | 0.47 (0.24, 0.91) | 0.46 (0.22, 0.94) | 0.66 | 0.49 (0.25, 0.96) | 0.47 (0.2, 1.08) | 0.95 | 0.97 | 0.32 |
Change | 0.93 (0.50, 1.71) | 0.93 (0.48, 1.78) | 0.85 | 0.93 (0.48, 1.79) | 0.91 (0.51, 1.63) | 0.41 | 0.68 | 0.75 |
THBS1 (ug/mL) | N = 172, 125 | N = 175, 124 |  | N = 145, 106 | N = 108, 108 |  |  |  |
Baseline | 1.98 (0.18, 21.35) | 2.10 (0.19, 23.82) | 0.44 | 1.85 (0.24, 14.36) | 2.36 (0.24, 23.08) | 0.02 | 0.35 | 0.14 |
Year 1 | 1.98 (0.2, 19.12) | 2.16 (0.19, 24.55) | 0.27 | 2.16 (0.27, 17.14) | 2.39 (0.25, 23) | 0.10 | 0.95 | 0.38 |
Change | 0.96 (0.12, 7.96) | 0.94 (0.13, 6.67) | 0.17 | 1.24 (0.16, 9.53) | 0.97 (0.16, 5.76) | 0.08 | 0.26 | 0.25 |
CFD (ug/mL) | N = 204, 139 | N = 202, 138 |  | N = 150, 108 | N = 131, 91 |  |  |  |
Baseline | 0.79 (0.35, 1.74) | 0.72 (0.37, 1.4) | 0.003 | 0.78 (0.36, 1.67) | 0.76 (0.4, 1.45) | 0.22 | 0.27 | 0.02 |
Year 1 | 0.75 (0.32, 1.73) | 0.7 (0.34, 1.42) | 0.05 | 0.81 (0.33, 1.98) | 0.77 (0.36, 1.65) | 0.20 | 0.75 | 0.09 |
Change | 0.98 (0.58, 1.65) | 0.96 (0.65, 1.43) | 0.26 | 1.04 (0.63, 1.70) | 1.01 (0.72, 1.44) | 0.22 | 0.95 | 0.30 |
IGFBP1 (ng/mL) | N = 201, 139 | N = 201, 138 |  | N = 150, 108 | N = 145, 105 |  |  |  |
Baseline | 10.98 (1.56, 77.48) | 10.71 (1.26, 90.8) | 0.77 | 9.21 (1.09, 77.72) | 7.61 (0.75, 76.76) | 0.19 | 0.32 | 0.25 |
Year 1 | 15.70 (1.85, 133.37) | 15.62 (1.81, 134.43) | 0.85 | 17.67 (1.49, 209.42) | 12.52 (0.91, 172.68) | 0.06 | 0.12 | 0.16 |
Change | 1.63 (0.33, 8.20) | 1.40 (0.24, 8.15) | 0.41 | 1.79 (0.37, 8.52) | 1.87 (0.27, 12.83) | 0.13 | 0.21 | 0.38 |
Stroke | ||||||||
 | E + P | E-alone | Difference between cohorts b | Overall case vs. control difference c | ||||
 | Cases | Controls | P value a | Cases | Controls | P value a | ||
N | 182 | 176 | Â | 180 | 170 | Â | Â | Â |
B2M (mg/mL) | N = 181, 146d | N = 174, 146d |  | N = 179, 141d | N = 170, 134d |  |  |  |
Baseline | 0.12 (0.04, 0.38) | 0.11 (0.06, 0.20) | 0.02 | 0.13 (0.06, 0.25) | 0.11 (0.06, 0.22) | 0.002 | 0.18 | 0.003 |
Year 1 | 0.12 (0.06, 0.26) | 0.11 (0.06, 0.21) | 0.03 | 0.13 (0.06, 0.27) | 0.12 (0.06, 0.24) | 0.06 | 0.84 | 0.001 |
Change | 1.05 (0.33, 3.32) | 0.99 (0.69, 1.40) | 0.32 | 1.03 (0.64, 1.65) | 1.04 (0.70, 1.56) | 0.99 | 0.20 | 0.31 |
IGFBP2 (ng/mL) | N = 171, 136 | N = 169, 139 |  | N = 164, 128 | N = 158, 125 |  |  |  |
Baseline | 80.9 (23.63, 276.99) | 73.52 (15.27, 353.91) | 0.53 | 72.55 (16.63, 316.48) | 67.38 (15.28, 297.04) | 0.36 | 0.85 | 0.14 |
Year 1 | 64.95 (16.88, 249.86) | 66.11 (17.02, 256.78) | 0.65 | 60.57 (12.3, 298.34) | 57.99 (12.4, 271.3) | 0.63 | 0.64 | 0.86 |
Change | 0.85 (0.33, 2.17) | 0.90 (0.40, 2.04) | 0.42 | 0.86 (0.34, 2.17) | 0.91 (0.32, 2.55) | 0.15 | 0.96 | 0.16 |
IGFBP4 (ug/mL) | N = 175, 139 | N = 170, 139 |  | N = 168, 131 | N = 164, 128 |  |  |  |
Baseline | 0.49 (0.22, 1.08) | 0.45 (0.18, 1.09) | 0.11 | 0.48 (0.21, 1.11) | 0.43 (0.20, 0.95) | 0.03 | 0.87 | 0.004 |
Year 1 | 0.56 (0.24, 1.35) | 0.52 (0.23, 1.16) | 0.05 | 0.57 (0.24, 1.39) | 0.5 (0.21, 1.18) | 0.01 | 0.47 | 0.003 |
Change | 1.05 (0.54, 2.05) | 1.05 (0.53, 2.10) | 0.76 | 1.10 (0.59, 2.07) | 1.03 (0.55, 1.93) | 0.08 | 0.24 | 0.59 |
IGFBP6 (ug/mL) | N = 166, 130 | N = 159, 133 |  | N = 161, 126 | N = 153, 118 |  |  |  |
Baseline | 0.15 (0.05, 0.43) | 0.14 (0.05, 0.4) | 0.56 | 0.15 (0.04, 0.47) | 0.14 (0.04, 0.55) | 0.99 | 0.89 | 0.55 |
Year 1 | 0.14 (0.05, 0.41) | 0.13 (0.03, 0.51) | 0.53 | 0.14 (0.04, 0.47) | 0.14 (0.03, 0.59) | 0.58 | 0.42 | 0.60 |
Change | 0.92 (0.31, 2.75) | 0.91 (0.25, 3.38) | 0.99 | 0.96 (0.28, 3.31) | 0.93 (0.33, 2.61) | 0.50 | 0.86 | 0.57 |
HPX (mg/mL) | N = 175, 140 | N = 170, 140 |  | N = 169, 131 | N = 164, 128 |  |  |  |
Baseline | 0.55 (0.33, 0.92) | 0.54 (0.31, 0.95) | 0.93 | 0.57 (0.31, 1.06) | 0.54 (0.31, 0.97) | 0.17 | 0.42 | 0.19 |
Year 1 | 0.52 (0.33, 0.82) | 0.52 (0.31, 0.87) | 0.95 | 0.54 (0.32, 0.9) | 0.53 (0.33, 0.83) | 0.35 | 0.78 | 0.42 |
Change | 1.00 (0.64, 1.58) | 0.99 (0.64, 1.51) | 0.50 | 1.02 (0.67, 1.55) | 1.04 (0.71, 1.52) | 0.71 | 0.38 | 0.09 |