|
CHD and stroke risk factors
|
Proteomic marker
|
|---|
| |
B2M
|
ORM1
|
THBS1
|
CFD
|
IGFBP1
|
IGFBP2
|
IGFBP4
|
IGFBP6
|
HPX
|
|---|
|
Lipids
| | | | | | | | | |
|
HDL-C
|
-0.16
|
-0.23
|
-0.10
|
-0.25
|
0.22
|
0.52
|
-0.25
|
-0.18
|
-0.21
|
|
(-0.27, -0.05)
|
(-0.36, -0.09)
|
(-0.24, 0.06)
|
(-0.38, -0.11)
|
(0.08, 0.36)
|
(0.37, 0.64)
|
(-0.41, -0.07)
|
(-0.36, 0.01)
|
(-0.38, -0.03)
|
|
LDL-C
|
-0.04
|
0.04
|
0.09
|
-0.01
|
-0.05
|
-0.15
|
0.01
|
0.02
|
0.14
|
|
(-0.15, 0.08)
|
(-0.10, 0.19)
|
(-0.06, 0.24)
|
(-0.16, 0.13)
|
(-0.19, 0.10)
|
(-0.32, 0.04)
|
(-0.18, 0.19)
|
(-0.17, 0.21)
|
(-0.04, 0.32)
|
|
Inflammatory markers
| | | | | | | | | |
|
CRP
|
-0.04
|
0.02
|
0.12
|
-0.04
|
0.05
|
-0.11
|
-0.02
|
-0.04
|
0.13
|
|
(-0.15, 0.08)
|
(-0.12, 0.17)
|
(-0.03, 0.27)
|
(-0.18, 0.11)
|
(-0.10, 0.19)
|
(-0.28, 0.08)
|
(-0.21, 0.16)
|
(-0.23, 0.15)
|
(-0.06, 0.30)
|
|
IL-6
|
0.09
|
0.30
|
0.09
|
0.05
|
-0.11
|
-0.16
|
0.30
|
0.21
|
0.23
|
|
(-0.03, 0.20)
|
(0.16, 0.43)
|
(-0.07, 0.24)
|
(-0.10, 0.20)
|
(-0.25, 0.04)
|
(-0.34, 0.03)
|
(0.12, 0.46)
|
(0.01, 0.39)
|
(0.05, 0.40)
|
|
MMP-9
|
0.08
|
0.30
|
-0.06
|
0.11
|
-0.06
|
-0.20
|
0.06
|
0.09
|
0.07
|
|
(-0.03, 0.20)
|
(0.16, 0.43)
|
(-0.21, 0.10)
|
(-0.03, 0.26)
|
(-0.20, 0.09)
|
(-0.37, -0.01)
|
(-0.12, 0.24)
|
(-0.11, 0.27)
|
(-0.11, 0.25)
|
|
Thrombosis and other blood markers
| | | | | | | | | |
|
Factor VIII
|
0.21
|
0.14
|
0.06
|
-0.02
|
0.08
|
-0.11
|
0.23
|
0.19
|
0.12
|
|
(0.10, 0.32)
|
(0.00, 0.28)
|
(-0.10, 0.21)
|
(-0.16, 0.12)
|
(-0.07, 0.22)
|
(-0.29, 0.08)
|
(0.05, 0.39)
|
(0.00, 0.37)
|
(-0.06, 0.30)
|
|
Factor 1.2
|
0.01
|
-0.04
|
-0.02
|
0.08
|
0.09
|
0.06
|
-0.02
|
0.06
|
0.31
|
|
(-0.10, 0.13)
|
(-0.18, 0.10)
|
(-0.18, 0.13)
|
(-0.07, 0.22)
|
(-0.06, 0.23)
|
(-0.13, 0.24)
|
(-0.20, 0.16)
|
(-0.13, 0.25)
|
(0.14, 0.47)
|
|
D-Dimer
|
-0.02
|
0.15
|
-0.10
|
0.08
|
0.11
|
-0.04
|
0.00
|
0.00
|
0.15
|
|
(-0.14, 0.10)
|
(0.00, 0.29)
|
(-0.26, 0.06)
|
(-0.07, 0.23)
|
(-0.04, 0.26)
|
(-0.23, 0.15)
|
(-0.19, 0.18)
|
(-0.19, 0.20)
|
(-0.04, 0.32)
|
|
vWF
|
0.13
|
0.22
|
0.08
|
0.36
|
-0.01
|
0.15
|
0.18
|
0.09
|
0.06
|
|
(0.02, 0.24)
|
(0.07, 0.35)
|
(-0.22, 0.08)
|
(0.23, 0.48)
|
(-0.16, 0.13)
|
(-0.03, 0.33)
|
(0.00, 0.35)
|
(-0.10, 0.28)
|
(-0.13, 0.24)
|
|
Insulin
|
0.23
|
-0.03
|
-0.01
|
0.19
|
-0.04
|
0.02
|
0.29
|
0.23
|
0.04
|
|
(0.12, 0.33)
|
(-0.17, 0.11)
|
(-0.16, 0.14)
|
(0.05, 0.32)
|
(-0.18, 0.11)
|
(-0.16, 0.21)
|
(0.11, 0.44)
|
(0.04, 0.40)
|
(-0.14, 0.22)
|
|
Glucose
|
0.03
|
0.17
|
0.02
|
0.24
|
-0.44
|
-0.13
|
0.29
|
0.28
|
0.26
|
|
(-0.08, 0.15)
|
(0.02, 0.31)
|
(-0.14, 0.17)
|
(0.10, 0.38)
|
(-0.55, -0.31)
|
(-0.31, 0.07)
|
(0.10, 0.45)
|
(0.08, 0.45)
|
(0.07, 0.43)
|
|
WBC
|
0.01
|
0.02
|
0.06
|
0.02
|
-0.10
|
-0.30
|
0.09
|
0.21
|
0.11
|
|
(-0.10, 0.12)
|
(-0.12, 0.17)
|
(-0.09, 0.21)
|
(-0.12, 0.16)
|
(-0.24, 0.04)
|
(-0.46, -0.12)
|
(-0.10, 0.27)
|
(0.02, 0.39)
|
(-0.08, 0.29)
|
|
Blood pressure
| | | | | | | | | |
|
Systolic BP
|
0.08
|
0.10
|
0.17
|
0.04
|
-0.03
|
-0.25
|
0.00
|
0.17
|
0.14
|
|
(-0.04, 0.19)
|
(-0.04, 0.24)
|
(0.02, 0.32)
|
(-0.11, 0.18)
|
(-0.17, 0.12)
|
(-0.42, -0.07)
|
(-0.18, 0.18)
|
(-0.02, 0.35)
|
(-0.04, 0.31)
|
|
Diastolic BP
|
0.18
|
0.08
|
-0.11
|
0.19
|
0.00
|
-0.06
|
0.18
|
0.18
|
0.05
|
| |
(0.08, 0.28)
|
(-0.06, 0.22)
|
(-0.25, 0.05)
|
(0.05, 0.32)
|
(-0.15, 0.14)
|
(-0.21, 0.09)
|
(0.03, 0.32)
|
(0.03, 0.33)
|
(-0.10, 0.19)
|
- Correlations are based on data from 357 controls drawn from the placebo groups of the WHI postmenopausal HT trials of estrogen plus progestin and estrogen-alone. Estimated correlations are bolded for ease of viewing.
- BP: blood pressure; CRP: C-reactive protein; Factor 1.2: prothrombin fragment 1.2; Factor VIII: clotting factor eight; HDL-C: high-density lipoprotein cholesterol; IL-6: interleukin 6; LDL-C: low-density lipoprotein cholesterol; MMP-9: matrix metallaprotinase-9; vWF: von villebrand factor; WBC: total leukocyte count; WHI: Women’s Health Initiative.
