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Table 1 Students’ interest in analyzing their own genomes in an educational setting

From: Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort study

N = 19 Response options T1 T2 T3 Significancec
Interest/decision N (%) N ( %) N ( %) T1 to T2 a T1 to T3 a T2 to T3 a
Would you want to analyze your own genome as part of an advanced WGS course? No, definitely not 0 (0%) 0 (0%) 0 (0%) z = −1.41, P = 0.16, r = −0.32 z= −2.46, P= 0.014, r= −0.56 z= −2.24, P= 0.025, r= −0.51
No, probably not 2 (10.5%) 0 (0%) 0 (0%)
Don’t know/It depends 0 (0%) 2 (10.5%) 0 (0%)
Yes, probably 10 (52.6%) 7 (36.8%) 6 (31.6%)
Yes, definitely 7 (36.8%) 10 (52.6%) 13 (68.4%)
Median Yes, probably Yes, definitely Yes, definitely
At this point, which of the following options would you prefer? Please check one. Option 1: I would like to analyze my own genome as part of an advanced WGS course. 17 (89.5%) 18 (94.7%) 18 (94.7%) z = −1.41, P = 0.16, r = −0.32 z = −0.58, P = 0.56, r = −0.13 z = −1.00, P = 0.32, r = −0.23
Option 2: I would not like to analyze my own genome as part of an advanced WGS course, and would rather analyze an anonymous donated genome. 2 (10.5%) 0 (0%) 0 (0%)
[Participant did not check either option] 0 (0%) 1 (5.3%) 1 (5.3%)
Decisional conflict: individual items (agree/strongly agree) N ( %) N ( %) N ( %) T1 to T2 a T1 to T3 a T2 to T3 a
I know which options are available to me. 17 (89.5%) 19 (100%) 18 (94.7%) z = −1.90, P = 0.058, r = −0.44 z= −2.45, P= 0.014, r= −0.56 z = 0.00, P = 0.99, r = 0.00
Median Agree Strongly agree Strongly agree
I know the benefits of each option. 13 (68.4%) 18 (94.7%) 18 (94.7%) z= −2.57, P= 0.010, r= −0.59 z= −3.00, P= 0.003, r= −0.69 z= −2.00, P= 0.046, r= −0.46
Median Agree Agree Strongly agree
I know the risks of each option. 9 (47.4%) 17 (89.5%) 18 (94.7%) z= −2.86, P= 0.004, r= −0.66 z= −3.41, P= 0.001, r= −0.78 z = −1.34, P = 0.18, r = 0.31
Median Neither Agree Agree
I am clear about which benefits matter most to me. 10 (55.6%) 16 (84.2%) 18 (94.7%) z= −2.51, P= 0.012, r= −0.58 z= −2.80, P= 0.005, r= −0.64 z = −0.38, P = 0.71, r = −0.08
Median Agree Agree Agree
I am clear about which risks matter most. 9 (47.4%) 16 (84.2%) 17 (89.5%) z= −2.41, P= 0.016, r= −0.55 z= −2.38, P= 0.017, r= −0.55 z = −0.07, P = 0.94, r = −0.02
Median Neither Agree Agree
I am clear about which is more important to me (the benefits or the risks). 11 (57.9%) 16 (84.2%) 17 (89.5%) z = −1.51, P = 0.13, r = −0.35 z= −2.23, P= 0.026, r= −0.53 z = −1.67, P = 0.096, r = 0.38
Median Agree Agree Agree
I have enough support from others to make a choice. 10 (52.6%) 18 (94.7%) 15 (78.9%) z= −2.88, P= 0.004, r= −0.66 z= −2.12, P= 0.034, r= −0.49 z = −0.92, P = 0.36, r = −0.21
Median Agree Agree Agree
I am choosing without pressure from others. 18 (94.7%) 17 (89.5%) 17 (89.5%) z = −0.63, P = 0.53, r = −0.14 z = −0.82, P = 0.41, r = 2.25 z = 0.00, P = 0.99, r = 0.00
Median Agree Strongly agree Strongly agree
I have enough advice to make a choice. 10 (52.6%) 14 (73.7%) 17 (89.5%) z= −2.44, P= 0.015, r= −0.56 z= −3.09, P= 0.002, r= −0.71 z = −1.73, P = 0.083, r = −0.40
Median Agree Agree Agree
I feel sure about what to choose. 11 (57.9%) 13 (68.4%) 15 (78.9%) z = −1.21, P = 0.23, r = −0.28 z = −1.96, P = 0.051, r = 0.45 z = −1.16, P = 0.25, r = −0.27
Median Agree Agree Agree
This decision is easy for me to make. 8 (42.1%) 12 (63.2%) 13 (68.4%) z = −1.73, P = 0.083, r = −0.40 z= −2.51, P= 0.012, r= 4.36 z = −1.40, P = 0.16, r = −0.32
Median Neither Agree Agree
I feel I have made an informed choice. 9 (47.4%) 16 (84.2%) 19 (100%) z= −2.88, P= 0.004, r= −0.66 z= −2.97, P= 0.003, r= −0.68 z = −1.13, P = 0.26, r = −0.26
Median Neither Agree Agree
My decision shows what is important to me. 12 (63.2%) 18 (94.7%) 15 (78.9%) z= −2.39, P= 0.017, r= −0.55 z= −2.33, P= 0.020, r= 4.36 z = −0.38, P = 0.71, r = 0.08
Median Agree Agree Agree
I expect to stick with my decision. 14 (73.7%) 15 (78.9%) 17 (89.5%) z = −0.92, P = 0.36, r = −0.21 z= −2.17, P= 0.030, r= 0.50 z = −1.13, P = 0.26, r = −0.26
Median Agree Agree Strongly agree
I am satisfied with my decision. 12 (63.2%) 15 (78.9%) 17 (89.5%) z= −2.65, P= 0.008, r= −0.61 z= −2.71, P= 0.007, r= 0.62 z = −1.00, P = 0.32, r = −0.23
Median Agree Agree Agree
Decisional conflict: overall scale and subscales Mean (SD), range Mean (SD), range Mean (SD), range T1 to T2 b T1 to T3 b T2 to T3 b
Overall decisional conflict scale 33.88 (18.18), 0.00 to 70.31 19.82 (14.24), 0.00 to 46.88 16.61 (14.55), 0.00 to 43.75 t (18) = 3.99, P= 0.001, r= 0.69 t (18) = 4.83, P< 0.001, r= 0.75 t(18) = 1.72, P = 0.10, r = 0.38
Subscales:       
Informed subscale 31.14 (21.31), 0.00 to 75.00 15.35 (12.19), 0.00 to 41.67 12.28 (13.99), 0.00 to 50.00 t (18) = 3.66, P= 0.002, r= 0.65 t (18) = 4.88, P< 0.001, r= 0.75 t(18) = 1.79, P = 0.090, r = 0.39
Effective decision-making (satisfaction) subscale 31.58 (19.82), 0.00 to 68.75 19.08 (15.23), 0.00 to 50.00 16.12 (15.63), 0.00 to 43.75 t (18) = 3.78, P= 0.001, r= 0.67 t (18) = 4.00, P= 0.001, r= 0.69 t(18) = 1.18, P = 0.25, r = 0.27
Support subscale 31.13 (17.97), 0.00 to 66.67 16.67 (14.43), 0.00 to 50.00 15.79 (17.10), 0.00 to 50.00 t (18) = 3.43, P= 0.003, r= 0.63 t (18) = 3.36, P= 0.003, r= 0.62 t(18) = 0.36, P = 0.73, r = 0.08
Values clarity subscale 35.09 (24.78), 0.00 to 75.00 20.18 (15.79), 0.00 to 50.00 17.11 (15.08), 0.00 to 50.00 t (18) = 2.79, P= 0.012, r= 0.55 t (18) = 3.23, P= 0.005, r= 0.61 t(18) = 0.94, P = 0.36, r = 0.22
Uncertainty subscale 40.79 (28.21), 0.00 to 75.00 32.24 (29.85), 0.00 to 100.00 25.00 (23.57), 0.00 to 75.00 t(18) = 1.95, P = 0.067, r = 0.42 t (18) = 3.13, P= 0.006, r= 0.59 t(18) = 1.57, P = 0.13, r = 0.35
  1. aDifferences assessed using Wilcoxon signed-rank test.
  2. bDifferences assessed using paired samples t-tests.
  3. cBold text in the Significance column highlights results that were significant at the P < 0.05 level.