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Figure 6 | Genome Medicine

Figure 6

From: Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa

Figure 6

Resolution stage of acute respiratory illness. (A) Comparative analysis of acute respiratory illness-associated genes of D6 with respect to BL revealed that the resolution stage was characterized by a core transcriptional profile regardless of disease status (box). Complete gene lists generated for each comparison are outlined in Table S1 in Additional file 2. (B) Kinetics of shared-D6 gene expression in each study group (nā€‰=ā€‰16/time point) (C) Hierarchical clustering analysis of the D6 versus BL microarray expression of the core-D6 genes. (D) Quantitative real-time PCR confirmation of select core-D6 gene expression. Horizontal line depicts mean. *P ā‰¤0.05. (E) Influence of medication use on core-D6 gene expression for all asthmatics. Horizontal line depicts mean. AQP9, Aquaporin 9; BL, baseline; GCN, fold change in normalized gene copy number; D2, day 2; D6, day 6; FCGR3A, Fc fragment of immunoglobulin G, low affinity IIIa, receptor (CD16a); KRT24, Keratin 24.

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