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Table 1 Demographic and clinical data of the study population

From: Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa

  Healthy Allrg Rhin Asm NoEx Asm Ex Total
Participants, n (%) 9 (18.0) 7 (14.0) 23 (46.0) 11 (22.0)a 50 (100.0)
Female, n (%) 7 (14.0) 3 (6.0) 18 (36.0) 10 (20.0) 38 (76.8)
Age; median years (max-min) 30 (18 to 37) 31 (20 to 47) 37 (19 to 66) 29 (25 to 46) 32 (18 to 66)
Ethnicity, n (%)      
White 8 (16.0) 5 (10.0) 13 (26.0) 9 (18.0) 35 (70.0)
African American 0 (0.0) 1 (2.0) 4 (8.0) 1 (2.0) 6 (12.0)
Hispanic 0 (0.0) 0 (0.0) 3 (6.0) 0 (0.0) 3 (6.0)
Other 1 (2.0) 1 (2.0) 3 (6.0) 1 (2.0) 6 (12.0)
Atopic, n (%) 1 (2.0) 7 (14.0) 18 (36.0) 8 (16.0) 34 (68.0)
Baseline PC 20 ; mean mg/mL (±SD) 28 (27.1) 6.7 (3.8) 4.5 (5.1) 4.4 (5.2) n/a
Baseline FEV1; mean% predicted (±SD) 98.3 (11.0) 105.8 (6.7) 97.8 (16.5) 91.2 (10.8) n/a
Medication, n (%)      
Inhaled corticosteroids 0 (0.0) 0 (0.0) 6 (12.0) 3 (6.0) 9 (18.0)
Inhaled corticosteroids plus long-acting beta agonists 0 (0.0) 0 (0.0) 2 (4.0) 1 (2.0) 3 (6.0)
Nasal steroids 0 (0.0) 0 (0.0) 6 (12.0) 3 (6.0) 9 (18.0)
Respiratory virus identification, n (%)      
Human rhinovirus 5 (10.0) 1 (2.0) 9 (18.0) 3 (6.0) 18 (36.0)
Respiratory syncytial virus 0 (0.0) 0 (0.0) 2 (4.0) 1 (2.0)b 3 (6.0)
Human coronavirus 1 (2.0) 1 (2.0) 2 (4.0) 2 (4.0)b 6 (12.0)
Influenza A virus 0 (0.0) 1 (2.0) 1 (2.0) 0 (0.0) 2 (4.0)
Human parainfluenza virus 0 (0.0) 1 (2.0) 0 (0.0) 0 (0.0) 1 (2.0)
No detection 3 (6.0) 3 (6.0) 9 (18.0) 5 (10.0) 20 (40.0)
  1. All bracketed values represent percentage of total participants unless otherwise stated. aAmong the Asm Ex group, n = 4 were classified because of increase/start of corticosteroid or need for medical care and n = 7 were classified due to increased symptoms accompanied by either an increase in albuterol (n = 5 out of 7) or a decline in FEV1 (n = 3 out 7) or peak expiratory flow (n = 6 out of 7). bIncludes dual detections. FEV1, forced expiratory volume in 1 s; PC20, provocative concentration of methacholine causing a 20% fall in FEV1; SD, standard deviation.