Homozygous deletion of STAG2 in metastatic PDA. A 4.5 N aneuploid population was detected and sorted in biopsies from the (A) primary and (B,C) two metastatic sites from rapid autopsy specimen UNMC 12R. (D) aCGH analysis of the sorted diploid (2.0 N; bottom) and the sorted 4.5 N (top) populations. Chromosome Xq25 CGH plots of (E) sorted 2.0 N population and (F) clonal homozygous deletion of STAG2 in the 4.5 N populations sorted from the pancreas (top panel), omentum (middle panel), and lung (bottom panel). Shaded areas in (E,F) denote ADM2 step gram defined genomic intervals.