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Table 1 Summary of included trials

From: Patient engagement as a risk factor in personalized health care: a systematic review of the literature on chronic disease

Study (year)

Disease or condition

N

Mean age (SD)

Sex

Intervention

Control

Intervention length

Follow up

Results*

Barlow et al. (2009)[31]

MS

216

I = 48.2 (10.1)

59 M

In-person group-based chronic disease self-management program

Wait-list control + comparison group

6 weeks (2 h/week)

4, 12 months

0 Self-management self-efficacy (P = 0.132, ES = 0.30)

C = 50.7 (11.7)

+ MSIS physical status (P = 0.005, ES = 0.21)

Comparison = 54.6 (10.8)

0 Improvement in depression (P = 0.632)

0 MS self-efficacy (P = 0.161)

0 cognitive symptom management (P = 0.140)

0 MD communication (P = 0.861)

Glasgow et al. (2012)[32]

Diabetes

463

I (CASM+) = 57.8 (9.3)

232 M

Internet-based diabetes self-management program with (CASM+) and without enhanced social support (CASM)

Enhanced usual care (computer-based health risk appraisal feedback with recommendations for preventive behaviors)

12 months (ongoing internet-based intervention); CASM + group also received three 120-minute group sessions and two follow-up calls

4, 12 months

+ Health behaviors (eating habits, fat intake, physical activity: P < 0.05, ES = 0.09-0.16)

I (CASM) = 58.7 (9.3)

+ Biological outcomes (lower HbA1c, improved lipid ratio, BP MAP, 10-year CHD risk: P < 0.05)

C = 58.7 (9.1)

+ Psychosocial and QOL measures (self-efficacy, problem solving, general health state, diabetes distress: P < 0.05)

0 Medication adherence

Goeppinger et al. (2007)[33]

Arthritis

416

I = 64 (12.78)

75 M

Arthritis self-help group: small group, in-person workshops specific to arthritis

Generic chronic disease self-management group: small group, in-person workshops not specific to arthritis

6 weekly sessions 2–2.5 h each

4, 12 months

+ Self-efficacy (P = 0.004)

C = 64 (12.8)

+ General health (P = 0.016)

+ Stretching minutes (P = 0.023)

+ Strengthening minutes (P = 0.016)

Hibbard et al. (2007)[34]

At least one of six chronic diseases (T2D, HTN, arthritis, CHD, COPD, hyperlipidemia)

479

I = 59.6

147 M

In-person group-based chronic disease self-management program

No intervention

6 weeks

6 months

0 Engagement (PAM) (P < 0.001)

C = 60.0

(2.5 h/1 wk)

+ General self-management behaviors (P < 0.05)

+Diabetes self-management behaviors (P < 0.05)

+Arthritis self-management behaviors (P < 0.05)

+ HRQoL (P = NR)

Huang et al. (2009)[35]

Asthma

148

I = NR

108 M

Individualized self-care education program, with and without peak flow monitoring (PFM)

Usual care

6 months

1, 6 months

+ Asthma self-care competence (P < 0.001)

I + PFM = NR

+ Asthma self-care behaviors (P < 0.001)

C = NR

Asthma self efficacy (P < 0.001)

0 Unscheduled health service usage

Lavery et al. (2011)[36]

Bronchiectasis

64

I = 60 (9)

29 M

In-person, group-based patient self-management program

Usual care

8 weeks (2.5 h/week)

3, 6 months

+ Self-efficacy in exercise (P = 0.02); to get information about disease (P = 0.03); to manage disease in general (P = 0.05); to do chores (P = 0.04); for social/recreational activities (P = 0.03); to manage symptoms (P < 0.01); to control/manage depression (P = 0.01)

0 Self-efficacy in obtaining help from community, family and friends (P = 0.06); communicate with physician (P = 0.85); to manage shortness of breath (P = 0.08)

+ Symptom reporting (P < 0.05)

+ Decreased QOL (P = 0.01)

+ Increase in self-reported health care use (P < 0.05)

0 IPQ-R score

0 Lung function

C = 60 (8)

Lorig et al. (2010)[37]

Diabetes

761

All = 54.3

206 M

Internet-based diabetes self-management program

Usual care

6 weeks

6, 18 months

+ Engagement (PAM) (P = 0.021)

+ Self-efficacy (P < 0/001)

+ Lower HbA1C (P < 0.05; ES = 0.111)

+ Lower HbA1C high subgroup baseline ≥7.0 (P = 0.01; ES = 0.499)

0 Health behavior and utilization

0 Exercise (P = 0.810)

Lorig et al. (2009)[38]

Diabetes

345

I = 67.7 (11.9)

124 M

Community-based, peer-led diabetes self-management program

Usual care

6 weeks

6, 12 months

+ Engagement (PAM) (P = 0.017)

(2.5 h/1 wk)

C = 65.4 (11.4)

+ Self-efficacy (P = 0.001)

 

0 Lower HbA1C

+ Hypoglycemia symptoms (P = 0.002; ES > 0.30)

0 Hyperglycemia symptoms

+ Healthy eating (P < 0.001; ES > 0.30)

+ Lower depression (P < 0.001)

+ Communication with providers (P = 0.016)

Moriyama et al. (2009)[39]

Diabetes

75

I = 66.4 (9.2)

30 M

In person, individual self-management education program

Usual care

12 months

3, 6, 9, 12 months

+ Lower body weight (P = 0.001)

+ Lower HbA1C (P = 0.049)

+ Self-efficacy (P = 0.001)

+ Dietary and exercise stages (P = 0.017 and P = 0.020)

+ Degree of goal attainment (P = NR)

+ QOL (P = 0.055)

+ Lower diastolic BP (P = 0.067)

+ Lower total cholesterol (P = 0.087)

C = 65.2 (8.5)

Wolever et al. (2010)[40]

Diabetes

56

I = 53.1 (8.29)

13 M

Integrative health coaching

Wait-list control

6 months

1 month

+ Engagement (PAM) (P < 0.001)

C = 52.8 (7.64)

(14 sessions, 0.5 h each)

+ Medication adherence (P < 0.005)

+ Perception of illness (P < 0.05)

+ Psychosocial health (P < 0.05)

0 Lower HbA1C (all subjects)

         

+ Lower HbA1C for high subgroup baseline >7.0 (P = 0.016; ES = 0.34)

  1. BP, blood pressure; BP MAP, blood pressure mean arterial pressure; C, control; CASM, computer-assisted self-monitoring; CHD, chronic heart disease; COPD, chronic obstructive pulmonary disease; ES, effect size; HRQOL, health-related quality of life; HTN, hypertension; I, intervention; IPQ-R, Illness Perception Questionnaire-Revised; M, male; MS, multiple sclerosis; MSIS, Multiple Sclerosis Impact Scale; NR, not reported; PAM, Patient Activation Measure; PFM, peak flow monitoring; QOL, quality of life; SD, standard deviation; T2D, type 2 diabetes.