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Table 2 Mutated genes and loci information for EGFR / KRAS -negative lung adenocarcinomas from our cohort, the expansion cohort, and The Cancer Genome Atlas cohort

From: Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

Gene Mutation frequency in our set (N = 16) Mutation frequency in expansion set (N = 40) Mutation frequency in TCGA set (N = 14) Total (N) AA substitution COSMIC v.65 Number of damage algorithms
TP53 - 6 of 40 2 of 14 8 of 70 K93R O 4 of 4
122_122del O n/a
Y124C O 4 of 4
C203F O 4 of 4
G206S O 4 of 4
R209W O 4 of 4
E219* O 2 of 4
G295A O 4 of 4
SETD2 1 of 16 2 of 40 1 of 14 4 of 70 R839* - 1 of 2
V1576F - 3 of 3
Q1981* - 2 of 2
K2067* - 0 of 1
CSMD3 1 of 16 1 of 40 2 of 14 4 of 70 P667S O 3 of 4
M1440I - 3 of 4
K1928N - 3 of 4
Y2028C - 3 of 4
PTPRC 2 of 16 1 of 40 - 3 of 70 Y444N O 3 of 4
T453M - 3 of 4
T1176M - 4 of 4
SYNE2 1 of 16 2 of 40 - 3 of 70 2579_2580del - n/a
E3880* - n/a
E3903K O 3 of 4
GRIN2A - 3 of 40 - 3 of 70 L307Q - 3 of 4
N886S O 0 of 4
T1069M O 3 of 4
CDH10 - 2 of 40 1 of 14 3 of 70 E171K O 4 of 4
D315H O 1 of 4
R472C O 4 of 4
ERBB2 - - 3 of 14 3 of 70 E740delinsEAYVM (2) - n/a
G746delinsVC O n/a
SMAD4 - - 3 of 14 3 of 70 S242* - 1 of 2
R361S O 4 of 4
D493N O 3 of 4
CDC27 2 of 16 - - 2 of 70 I235T - 4 of 4
A273G O 3 of 4
GABRG1 2 of 16 - - 2 of 70 D43N - 2 of 4
T318S - 3 of 4
YTHDF1 2 of 16 - - 2 of 70 I492V (2) - 4 of 4
PCDHB14 2 of 16 - - 2 of 70 Y670S (2) - 2 of 3
MECP2 1 of 16 - 1 of 14 2 of 70 R168L - 2 of 3
G273V O 3 of 3
NRAS - 2 of 40 - 2 of 70 Q61H O 2 of 4
Q61K O 3 of 4
MET - - 2 of 14 2 of 70 Y1021* - 2 of 2
1027_1028del - NA
EPHA2 - 2 of 40 - 2 of 70 P147L O 4 of 4
P278S O 2 of 4
CHD2 - 2 of 40 - 2 of 70 S391fs - n/a
splicing(c.5153) O n/a
MST1 - - 2 of 14 2 of 70 406_407del - n/a
R535G - 3 of 4
ERBB4 1 of 16 - - 1 of 70 V840I O 4 of 4
PIK3CA 1 of 16 - - 1 of 70 G118D O 2 of 3
AKT2 1 of 16 - - 1 of 70 D153Y - 4 of 4
TSC1 1 of 16 - - 1 of 70 Q793* - 2 of 2
CTNNB1 1 of 16 - - 1 of 70 S37C O 4 of 4
TGFBR2 1 of 16 - - 1 of 70 R504W O 4 of 4
PBRM1 1 of 16 - - 1 of 70 E830* - 2 of 2
MBD2 1 of 16 - - 1 of 70 E373K - 4 of 4
CHEK2 1 of 16 - - 1 of 70 R191G - 3 of 4
PARP4 1 of 16 - - 1 of 70 I1039T O 4 of 4
CUL3 1 of 16 - - 1 of 70 Q516* - 2 of 2
SOD2 1 of 16 - - 1 of 70 K194E - 3 of 4
GABRD 1 of 16 - - 1 of 70 D174E - 4 of 4
NDRG1 1 of 16 - - 1 of 70 L257fs - n/a
TFG 1 of 16 - - 1 of 70 E240* - 1 of 1
SYK 1 of 16 - - 1 of 70 A400S - 4 of 4
ASPSCR1 1 of 16 - - 1 of 70 L252Q - 3 of 3
PCDHB15 1 of 16 - - 1 of 70 Y670S - 3 of 3
  1. COSMIC, Catalogue of Somatic Mutations in Cancer; n/a, not available; TCGA, The Cancer Genome Atlas.