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Table 2 Mutated genes and loci information for EGFR / KRAS -negative lung adenocarcinomas from our cohort, the expansion cohort, and The Cancer Genome Atlas cohort

From: Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

Gene

Mutation frequency in our set (N = 16)

Mutation frequency in expansion set (N = 40)

Mutation frequency in TCGA set (N = 14)

Total (N)

AA substitution

COSMIC v.65

Number of damage algorithms

TP53

-

6 of 40

2 of 14

8 of 70

K93R

O

4 of 4

122_122del

O

n/a

Y124C

O

4 of 4

C203F

O

4 of 4

G206S

O

4 of 4

R209W

O

4 of 4

E219*

O

2 of 4

G295A

O

4 of 4

SETD2

1 of 16

2 of 40

1 of 14

4 of 70

R839*

-

1 of 2

V1576F

-

3 of 3

Q1981*

-

2 of 2

K2067*

-

0 of 1

CSMD3

1 of 16

1 of 40

2 of 14

4 of 70

P667S

O

3 of 4

M1440I

-

3 of 4

K1928N

-

3 of 4

Y2028C

-

3 of 4

PTPRC

2 of 16

1 of 40

-

3 of 70

Y444N

O

3 of 4

T453M

-

3 of 4

T1176M

-

4 of 4

SYNE2

1 of 16

2 of 40

-

3 of 70

2579_2580del

-

n/a

E3880*

-

n/a

E3903K

O

3 of 4

GRIN2A

-

3 of 40

-

3 of 70

L307Q

-

3 of 4

N886S

O

0 of 4

T1069M

O

3 of 4

CDH10

-

2 of 40

1 of 14

3 of 70

E171K

O

4 of 4

D315H

O

1 of 4

R472C

O

4 of 4

ERBB2

-

-

3 of 14

3 of 70

E740delinsEAYVM (2)

-

n/a

G746delinsVC

O

n/a

SMAD4

-

-

3 of 14

3 of 70

S242*

-

1 of 2

R361S

O

4 of 4

D493N

O

3 of 4

CDC27

2 of 16

-

-

2 of 70

I235T

-

4 of 4

A273G

O

3 of 4

GABRG1

2 of 16

-

-

2 of 70

D43N

-

2 of 4

T318S

-

3 of 4

YTHDF1

2 of 16

-

-

2 of 70

I492V (2)

-

4 of 4

PCDHB14

2 of 16

-

-

2 of 70

Y670S (2)

-

2 of 3

MECP2

1 of 16

-

1 of 14

2 of 70

R168L

-

2 of 3

G273V

O

3 of 3

NRAS

-

2 of 40

-

2 of 70

Q61H

O

2 of 4

Q61K

O

3 of 4

MET

-

-

2 of 14

2 of 70

Y1021*

-

2 of 2

1027_1028del

-

NA

EPHA2

-

2 of 40

-

2 of 70

P147L

O

4 of 4

P278S

O

2 of 4

CHD2

-

2 of 40

-

2 of 70

S391fs

-

n/a

splicing(c.5153)

O

n/a

MST1

-

-

2 of 14

2 of 70

406_407del

-

n/a

R535G

-

3 of 4

ERBB4

1 of 16

-

-

1 of 70

V840I

O

4 of 4

PIK3CA

1 of 16

-

-

1 of 70

G118D

O

2 of 3

AKT2

1 of 16

-

-

1 of 70

D153Y

-

4 of 4

TSC1

1 of 16

-

-

1 of 70

Q793*

-

2 of 2

CTNNB1

1 of 16

-

-

1 of 70

S37C

O

4 of 4

TGFBR2

1 of 16

-

-

1 of 70

R504W

O

4 of 4

PBRM1

1 of 16

-

-

1 of 70

E830*

-

2 of 2

MBD2

1 of 16

-

-

1 of 70

E373K

-

4 of 4

CHEK2

1 of 16

-

-

1 of 70

R191G

-

3 of 4

PARP4

1 of 16

-

-

1 of 70

I1039T

O

4 of 4

CUL3

1 of 16

-

-

1 of 70

Q516*

-

2 of 2

SOD2

1 of 16

-

-

1 of 70

K194E

-

3 of 4

GABRD

1 of 16

-

-

1 of 70

D174E

-

4 of 4

NDRG1

1 of 16

-

-

1 of 70

L257fs

-

n/a

TFG

1 of 16

-

-

1 of 70

E240*

-

1 of 1

SYK

1 of 16

-

-

1 of 70

A400S

-

4 of 4

ASPSCR1

1 of 16

-

-

1 of 70

L252Q

-

3 of 3

PCDHB15

1 of 16

-

-

1 of 70

Y670S

-

3 of 3

  1. COSMIC, Catalogue of Somatic Mutations in Cancer; n/a, not available; TCGA, The Cancer Genome Atlas.
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Genome Medicine

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