Figure 4
Human s-DMRs in CpG islands versus CpG island shores. Number of hypo- and hypermethylated s-DMRs for island (77 and 45) and shore (821 and 431), respectively, is corrected for proportion of genome size (genomic space for islands = 23.8 Mb and for shores = 89.5 Mb). Directly comparing island and shore s-DMRs with regard to possible locations of hypomethylated s-DMRs (all co-locating chimpanzee and rhesus macaque peaks in these regions), χ2P = 2.90 × 10-29, and hypermethylated s-DMRs (from all location of human peaks in these regions), χ2P = 1.93 × 10-8; combined χ2P = 1.80 × 10-32. Therefore, human-specific peaks are more likely than non-human-specific peaks to reside within CpGi shores.