Conditional analysis | Mendelian randomization | Structural equation modeling | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
KORA | TwinsUK | KORA | TwinsUK | KORA | TwinsUK | ||||||
Locus | SNP - MET - LIP | Beta | Beta | Beta | Beta | Beta | Beta | 95% CI for Beta (MET → LIP using SNP as an IV) | 90% CI for Beta (MET → LIP using SNP as an IV) | Best fitted model | Best fitted model |
(LIP ~ SNP) | (LIP ~ SNP + MET) | Changes | (LIP ~ SNP) | (LIP ~ SNP + MET) | Changes | ||||||
GCKR | rs1260326 - PC aa C40:5 - TC | 2.789 | 0.685 | −75% | 4.770 | 2.747 | −42% | 0.34, 177.04 | −21.33, 168.93 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) |
rs1260326 - PC aa C40:5 - TG | 0.081 | 0.054 | −33% | 0.075 | 0.058 | −24% | 0.28, 3.86 | −0.38, 2.30 | Model 8 (SNP → LIP → MET) | ||
LPA | rs1564348 - C3 - HDL-C | 1.095 | 1.640 | 50% | 0.248 | 1.171 | 372% | −26.39, 46.60 | −50.74, 35.81 | ||
rs1564348 - C8:1 - HDL-C | 1.095 | 1.328 | 21% | 0.248 | 1.319 | 432% | −24.00, 35.48 | −16.69, 16.23 | |||
FADS1 | rs174546 - PC aa C32:0 - TG | 0.043 | 0.061 | 43% | 0.048 | 0.050 | 3% | −2.02, 0.35 | −2.45, 2.68 | Model 10 (MET ← SNP → LIP) | |
rs174546 - PC aa C32:2 - TG | 0.043 | 0.017 | −61% | 0.048 | 0.034 | −29% | 0.02, 0.88 | −0.59, 1.56 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C34:2 - TG | 0.043 | 0.006 | −87% | 0.048 | 0.037 | −22% | 0.20, 2.25 | −0.52, 1.75 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C34:3 - TG | 0.043 | 0.021 | −50% | 0.048 | 0.035 | −27% | −0.41, 2.08 | −1.09, 1.87 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C34:4 - TG | 0.043 | 0.102 | 139% | 0.048 | 0.076 | 58% | −0.77, 0.04 | −1.13, 0.44 | |||
rs174546 - PC aa C36:2 - TG | 0.043 | 0.004 | −90% | 0.048 | 0.041 | −15% | 0.14, 1.78 | −1.20, 2.20 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C36:3 - TG | 0.043 | −0.016 | −138% | 0.048 | 0.022 | −54% | 0.20, 1.55 | −0.10, 1.43 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C36:4 - TG | 0.043 | 0.157 | 268% | 0.048 | 0.084 | 75% | −0.72, −0.02 | −0.83, 0.07 | |||
rs174546 - PC aa C36:5 - TG | 0.043 | 0.077 | 79% | 0.048 | 0.054 | 13% | −0.54, 0.03 | −0.95, 0.12 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC aa C36:6 - TG | 0.043 | 0.060 | 40% | 0.048 | 0.053 | 10% | −1.52, 0.73 | −1.92, 2.04 | |||
rs174546 - PC aa C38:4 - TG | 0.043 | 0.177 | 315% | 0.048 | 0.097 | 102% | −0.59, 0.01 | −0.67, 0.06 | |||
rs174546 - PC aa C38:5 - TG | 0.043 | 0.131 | 206% | 0.048 | 0.069 | 44% | −0.74, −0.02 | −0.96, 0.07 | |||
rs174546 - PC aa C40:4 - TG | 0.043 | 0.103 | 140% | 0.048 | 0.076 | 58% | −1.10, 0.13 | −1.27, 0.44 | |||
rs174546 - PC aa C40:5 - TG | 0.043 | 0.115 | 168% | 0.048 | 0.077 | 60% | −1.07, 0.15 | −1.22, 0.33 | |||
rs174546 - PC aa C40:6 - TG | 0.043 | 0.071 | 65% | 0.048 | 0.055 | 14% | −1.84, 0.84 | −2.20, 2.10 | |||
rs174546 - PC aa C42:0 - TG | 0.043 | 0.025 | −41% | 0.048 | 0.030 | −37% | −2.62, 0.72 | −1.73, 0.53 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C42:1 - TG | 0.043 | 0.016 | −62% | 0.048 | 0.030 | −38% | −1.39, −0.07 | −1.24, 0.15 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC aa C42:4 - TG | 0.043 | 0.054 | 26% | 0.048 | 0.051 | 6% | −1.29, 0.03 | −1.20, 0.63 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC aa C42:6 - TG | 0.043 | 0.067 | 57% | 0.048 | 0.048 | 0% | −1.77, 0.33 | −1.76, 0.48 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC ae C36:2 - TG | 0.043 | 0.058 | 36% | 0.048 | 0.054 | 12% | −0.06, 1.14 | −3.89, 2.77 | |||
rs174546 - PC ae C36:3 - TG | 0.043 | 0.069 | 61% | 0.048 | 0.062 | 29% | −0.01, 1.03 | −0.76, 1.89 | |||
rs174546 - PC ae C36:4 - TG | 0.043 | 0.044 | 2% | 0.048 | 0.037 | −23% | −1.39, 0.11 | −1.13, 0.10 | Model 4 (SNP → MET → LIP) | ||
rs174546 - PC ae C36:5 - TG | 0.043 | 0.031 | −29% | 0.048 | 0.016 | −66% | −0.93, −0.07 | −0.84, 0.02 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C38:4 - TG | 0.043 | 0.036 | −16% | 0.048 | 0.044 | −8% | −1.10, −0.06 | −1.01, 0.07 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC ae C38:5 - TG | 0.043 | 0.030 | −30% | 0.048 | 0.022 | −55% | −1.18, −0.05 | −1.02, −0.01 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C38:6 - TG | 0.043 | 0.039 | −10% | 0.048 | 0.030 | −37% | −1.99, 0.18 | −1.52, 0.13 | Model 4 (SNP → MET → LIP) | ||
rs174546 - PC ae C40:1 - TG | 0.043 | 0.056 | 30% | 0.048 | 0.046 | −3% | −1.19, 0.10 | −2.02, 1.04 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC ae C40:4 - TG | 0.043 | 0.013 | −71% | 0.048 | 0.049 | 2% | −1.36, −0.08 | −1.20, 0.23 | Model 4 (SNP → MET → LIP) | Model 10 (MET ← SNP → LIP) | |
rs174546 - PC ae C40:5 - TG | 0.043 | 0.014 | −68% | 0.048 | 0.042 | −13% | −1.35, −0.05 | −1.26, 0.19 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C40:6 - TG | 0.043 | 0.037 | −13% | 0.048 | 0.034 | −29% | −2.90, 2.54 | −1.99, 0.64 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C42:1 - TG | 0.043 | 0.060 | 41% | 0.048 | 0.051 | 6% | −1.81, 0.26 | −1.74, 1.72 | Model 10 (MET ← SNP → LIP) | ||
rs174546 - PC ae C42:5 - TG | 0.043 | −0.003 | −106% | 0.048 | 0.031 | −36% | −1.43, −0.11 | −1.35, 0.15 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C44:5 – TG | 0.043 | −0.001 | −102% | 0.048 | 0.022 | −54% | −1.26, −0.14 | −1.16, 0.12 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) | |
rs174546 - PC ae C44:6 – TG | 0.043 | −0.007 | −117% | 0.048 | 0.006 | −87% | −1.10, −0.10 | −1.02, −0.05 | Model 4 (SNP → MET → LIP) | Model 4 (SNP → MET → LIP) |