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Table 1 Characteristics of screened compounds

From: A genome scale overexpression screen to reveal drug activity in human cells

Drug name Screen concentration Category* Clinical use Known target(s) Reference
Methotrexate 60 nM Antimetabolites/ immunosuppressants Antineoplastic DHFR [20]
Antirheumatic
Dermatologic agent
Aminopterin 20 nM Antimetabolites (discontinued) Dermatologic agent (phase I) DHFR, FPGS(?) [21]
Antineoplastic agent (phase II)
Orlistat 20 μM Antiobesity preparations, excluding diet products Anti-obesity agent LPL [22]
PNLIP [23]
FASN
Bleomycin 1 μM Cytotoxic antibiotics and related substances Antineoplastic agent DNA [24]
LIG1
LIG3
Cisplatin 2 μM Other antineoplastic agents Antineoplastic agent DNA [25]
Mitomycin C 80 nM Cytotoxic antibiotics and related substances Antineoplastic agent DNA [26]
17_DMAG 70 nM Experimental Hsp90 inhibitor Antineoplastic agent (phases I and II) Hsp90 [27]
HSP90AA1
HSP90AA2
HSP90B1
HSP90AB1