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Table 2 Validated hits

From: A genome scale overexpression screen to reveal drug activity in human cells

Drug Gene name Accession number Description Number of validated/tested candidate genes
Methotrexate DHFR BC000192 Dihydrofolate reductase 1/3
Aminopterin DHFR BC000192 Dihydrofolate reductase 1/9
Bleomycin IMMT BC002412 Inner membrane protein, mitochondrial (mitofilin) 2/30
STX3 BC007405 Syntaxin 3
Cisplatin MAP2K1IP1 BC026245 Mitogen-activated protein kinase kinase 1 interacting protein 1 4/15
MMD BC026324 Monocyte to macrophage differentiation-associated
PTPN2 BC016727 Protein tyrosine phosphatase, non-receptor type 2
RHOXF2 BC021719 Rhox homeobox family, member 2
Mitomycin C C20orf54 BC009750 Chromosome 20 open reading frame 54 8/19
CCDC45 BC009518 Coiled-coil domain containing 45
ELF5 BC029743 E74-like factor 5 (ets domain transcription factor)
PTPN2 BC008244 Protein tyrosine phosphatase, non-receptor type 2
RHOXF2 BC021719 Rhox homeobox family, member 2
TMEM150 BC050466 Transmembrane protein 150
USPL1 BC038103 Ubiquitin specific peptidase like 1
ZFP64 BC012759 Zinc finger protein 64 homolog (mouse)
17-DMAG EIF4B BC073139 Eukaryotic translation initiation factor 4B 1/29
Orlistat MGLL BC006230 Monoglyceride lipase 2/18
PON3 BC070374 Paraoxonase 3