Table 2 Validated hits
From: A genome scale overexpression screen to reveal drug activity in human cells
Drug | Gene name | Accession number | Description | Number of validated/tested candidate genes |
|---|---|---|---|---|
Methotrexate | DHFR | BC000192 | Dihydrofolate reductase | 1/3 |
Aminopterin | DHFR | BC000192 | Dihydrofolate reductase | 1/9 |
Bleomycin | IMMT | BC002412 | Inner membrane protein, mitochondrial (mitofilin) | 2/30 |
STX3 | BC007405 | Syntaxin 3 | ||
Cisplatin | MAP2K1IP1 | BC026245 | Mitogen-activated protein kinase kinase 1 interacting protein 1 | 4/15 |
MMD | BC026324 | Monocyte to macrophage differentiation-associated | ||
PTPN2 | BC016727 | Protein tyrosine phosphatase, non-receptor type 2 | ||
RHOXF2 | BC021719 | Rhox homeobox family, member 2 | ||
Mitomycin C | C20orf54 | BC009750 | Chromosome 20 open reading frame 54 | 8/19 |
CCDC45 | BC009518 | Coiled-coil domain containing 45 | ||
ELF5 | BC029743 | E74-like factor 5 (ets domain transcription factor) | ||
PTPN2 | BC008244 | Protein tyrosine phosphatase, non-receptor type 2 | ||
RHOXF2 | BC021719 | Rhox homeobox family, member 2 | ||
TMEM150 | BC050466 | Transmembrane protein 150 | ||
USPL1 | BC038103 | Ubiquitin specific peptidase like 1 | ||
ZFP64 | BC012759 | Zinc finger protein 64 homolog (mouse) | ||
17-DMAG | EIF4B | BC073139 | Eukaryotic translation initiation factor 4B | 1/29 |
Orlistat | MGLL | BC006230 | Monoglyceride lipase | 2/18 |
PON3 | BC070374 | Paraoxonase 3 |