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Figure 5 | Genome Medicine

Figure 5

From: Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivity

Figure 5

Differential coexpression among 263 genes differentially expressed by letrozole treatment. Two independent data sets of ER+ breast tumor samples were used. Coexpression was calculated as the first-order Spearman’s correlation coefficient for each pairwise combination of genes. In both the (a) discovery and (b) validation data sets, most coexpression relationships are unique to one of the two treatment conditions with an increase in the number of letrozole-induced coexpressed gene pairs. PostTx, post-treatment; PreTx, pre-treatment.

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