Figure 6

Letrozole-induced tumor adaptation is validated through replication of coexpressed gene pairs in the residual tumors. To make functional connections among gene pairs that have not been annotated to the same biological pathways, we used IMP, a web-based tool that mines empirical data to provide a predictive probability that two genes have a functional relationship. (a) We identified a functional subnetwork that implicates LINC00341, a long-non-coding RNA of unknown function, in ER-mediated repression. (b) We uncovered a functional subnetwork of genes associated with the EMT, a process that promotes tumor metastasis. Dotted lines indicate coexpression relationships. Solid lines indicate functional relationships determined by IMP with a predictive probability of at least 0.70. EMT, epithelial-to-mesenchymal transition.