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Table 1 Genes recurrently mutated in MNA

From: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin

Gene N. MNA mutated FRRa Fraction of samples mutated (MNA | CRCb) Link to oncogenesis
KRAS 10 0 1 | 0.42 Cancer Gene Census: pancreatic, colorectal, lung
GNAS 9 0 0.9 | 0.06 Cancer Gene Census: pituitary tumors
POM121L12 2 0 0.2 | 0.02  
DOK6 2 0 0.2 | 0.02 RET signaling
IRX6 2 0.001 0.2 | 0.02 Homeobox TF neurogenesis
KRT37 2 0.001 0.2 | 0.02  
EEF1A1 2 0.003 0.2 | 0.01 Proto-oncogene of PTI1: Prost. Tumor Inducing 1
CRY2 2 0.003 0.2 | 0.01  
SMAD2 2 0.004 0.2 | 0.04 TFGβ pathway
SNTG1 2 0.004 0.2 | 0.02  
OCA2 2 0.007 0.2 | 0.03  
EPHA10 2 0.007 0.2 | 0.02 Receptor for EPH pathway
ZNF512B 2 0.008 0.2 | 0.03  
PTCHD3 2 0.009 0.2 | 0.04 Homologous to PTCH1: Shh receptor
ANKRD24 2 0.009 0.2 | 0.02  
DCLK1 2 0.011 0.2 | 0.05 Intestinal tumor stem cell marker
PCDH10 2 0.011 0.2 | 0.09 Silenced in multiple epithelial cancers
MTIF2 2 0.014 0.2 | 0.02  
ITGA11 2 0.014 0.2 | 0.02  
COL5A3 2 0.014 0.2 | 0.04  
PCDH17 2 0.015 0.2 | 0.08 Mutated and silenced in GI cancer
CNTNAP2 2 0.018 0.2 | 0.06 Tumor suppressor in Gliomas
TRPS1 2 0.022 0.2 | 0.09 GATA factor involved in EMT in breast cancer
ABCA7 2 0.04 0.2 | 0.06  
FAT4 3 0.045 0.3 | 0.2 Putative receptor of Hippo pathway
DOCK3 2 0.061 NA  
ZNF469 2 0.067 NA  
SPTA1 2 0.068 NA  
COL6A3 2 0.089 NA  
LAMA1 2 0.105 NA  
APOB 2 0.261 NA  
CSMD1 2 0.305 NA  
MUC16 2 0.659 NA  
TTN 2 0.992 NA  
  1. aFalse recurrence rate (FRR) <0.05 are in bold.
  2. bMutSig significant (P <0.01).