Table 1 Genes recurrently mutated in MNA

KRAS

10

0

1 | 0.42

Cancer Gene Census: pancreatic, colorectal, lung

GNAS

9

0

0.9 | 0.06

Cancer Gene Census: pituitary tumors

POM121L12

2

0

0.2 | 0.02

DOK6

2

0

0.2 | 0.02

RET signaling

IRX6

2

0.001

0.2 | 0.02

Homeobox TF neurogenesis

KRT37

2

0.001

0.2 | 0.02

EEF1A1

2

0.003

0.2 | 0.01

Proto-oncogene of PTI1: Prost. Tumor Inducing 1

CRY2

2

0.003

0.2 | 0.01

SMAD2

2

0.004

0.2 | 0.04

TFGβ pathway

SNTG1

2

0.004

0.2 | 0.02

OCA2

2

0.007

0.2 | 0.03

EPHA10

2

0.007

0.2 | 0.02

Receptor for EPH pathway

ZNF512B

2

0.008

0.2 | 0.03

PTCHD3

2

0.009

0.2 | 0.04

Homologous to PTCH1: Shh receptor

ANKRD24

2

0.009

0.2 | 0.02

DCLK1

2

0.011

0.2 | 0.05

Intestinal tumor stem cell marker

PCDH10

2

0.011

0.2 | 0.09

Silenced in multiple epithelial cancers

MTIF2

2

0.014

0.2 | 0.02

ITGA11

2

0.014

0.2 | 0.02

COL5A3

2

0.014

0.2 | 0.04

PCDH17

2

0.015

0.2 | 0.08

Mutated and silenced in GI cancer

CNTNAP2

2

0.018

0.2 | 0.06

Tumor suppressor in Gliomas

TRPS1

2

0.022

0.2 | 0.09

GATA factor involved in EMT in breast cancer

ABCA7

2

0.04

0.2 | 0.06

FAT4

3

0.045

0.3 | 0.2

Putative receptor of Hippo pathway

DOCK3

2

0.061

NA

ZNF469

2

0.067

NA

SPTA1

2

0.068

NA

COL6A3

2

0.089

NA

LAMA1

2

0.105

NA

APOB

2

0.261

NA

CSMD1

2

0.305

NA

MUC16

2

0.659

NA

TTN

2

0.992

NA