Figure 3

eQTL analyses. (A-C) Plots of significance (NLP) of local eSNPs with a transcript probe located within 250 kb of the SNP, contrasting the full Caucasian sample in the discovery phase with the same sample minus all individuals experiencing an MI. (A) The full range; (B) eSNPs in the range 5 < NLP < 15. Colored points differ between the full and non-AMI samples by at least 0.5 NLP units, red indicating higher significance in the smaller sample, and blue higher significance in the full sample. (C) The same analysis as (B) but missing 39 individuals with the highest axis 5 scores who were not experiencing an MI. Numbers show the number of eSNPs in the red and blue categories across the full range of NLP >3. (D,E) Representative plots of transcript abundance by genotype, colored with respect to MI status (red experiencing an MI, blue no-MI). Lines show the slope of the two classes, indicating an interaction effect in (D) but no interaction effect in (E).