Table 1 Baseline characteristics
Baseline characteristics | All subjects (N = 338) | Discovery cohort (N = 175) | Replication cohort (N = 163) | AMI (N = 60) | No AMI (N = 278) | P-value |
|---|---|---|---|---|---|---|
Age (years) | 62 ± 11 | 67 ± 10 | 56 ± 10 | 65 ± 11 | 61 ± 11 | 0.014 |
Male gender (%) | 218 (65) | 112 (64) | 106 (65) | 47 (78) | 171 (62) | 0.015 |
Caucasian race (%) | 331 (98) | 170 (97) | 163 (100) | 58 (97) | 273 (99) | 0.19 |
Systolic blood pressure (mmHg) | 138 ± 23 | 142 ± 23 | 133 ± 21 | 135 ± 23 | 138 ± 23 | 0.36 |
BMI (kg/m2) | 30 ± 7 | 29 ± 6 | 31 ± 8 | 29.6 ± 6.8 | 30.2 ± 7.0 | 0.53 |
Serum creatinine (mg/dl) | 1.3 ± 1.1 | 1.3 ± 1.4 | 1.2 ± 0.7 | 1.6 ± 2.2 | 1.2 ± 0.7 | 0.009 |
Acute MI (%) | 60 (18) | 37 (21) | 23 (14) | - | - | - |
Old MI (%) | 109 (32) | 61 (35) | 48 (30) | 13 (22) | 96 (35) | 0.060 |
Current smoking (%) | 73 (22) | 34 (19) | 39 (24) | 8 (14) | 65 (24) | 0.09 |
Diabetes (%) | 120 (36) | 65 (37) | 55 (34) | 29 (48) | 91 (33) | 0.024 |
Hypertension (%) | 258 (77) | 142 (81) | 116 (72) | 46 (77) | 212 (77) | 0.98 |
Dyslipidemia (%) | 263 (78) | 133 (79) | 102 (77) | 47 (78) | 216 (78) | 0.95 |
Chronic heart failure (%) | 76 (23) | 41 (24) | 35 (21) | 15 (25) | 61 (22) | 0.61 |
LVEF (%) | 54 ± 11 | 54 ± 11 | 54 ± 11 | 51 ± 11 | 54 ± 11 | 0.06 |
HDL (mg/dl) | 43 ± 15 | 44 ± 14 | 41 ± 16 | 38 ± 14 | 44 ± 15 | 0.014 |
LDL (mg/dl) | 92 ± 37 | 91 ± 36 | 94 ± 38 | 85 ± 33 | 94 ± 37 | 0.13 |
Triglyceride (mg/dl) | 159 ± 115 | 150 ± 93 | 170 ± 137 | 154 ± 107 | 160 ± 117 | 0.73 |
Total cholesterol (mg/dl) | 166 ± 45 | 164 ± 42 | 169 ± 48 | 153 ± 35 | 169 ± 47 | 0.02 |
History of CABG (%) | 73 (21) | 42 (24) | 31 (19) | 13 (22) | 60 (22) | 0.99 |
Gensini score | 35 ± 54 | 38 ± 57 | 31 ± 55 | 48 ± 54 | 32 ± 54 | 0.046 |
Aspirin use (%) | 83 | 131 (81) | 131 (84) | 48 (89) | 214 (82) | 0.2 |
Beta blocker use (%) | 213 (67) | 107 (67) | 106 (67) | 45 (82) | 168 (64) | 0.012 |
Clopidogrel use (%) | 171 (55) | 91 (56) | 80 (53) | 34 (64) | 137 (53) | 0.13 |
ACE-inh/ARB use (%) | 192 (61) | 100 (62) | 92 (61) | 35 (67) | 157 (60) | 0.35 |
Statin use (%) | 244 (78) | 129 (80) | 115 (76) | 44 (83) | 200 (77) | 0.33 |
>50% stenosis (in any major epicardial artery (%) | 235 (70) | 133 (76) | 102 (64) | 59 (93) | 176 (64) | <0.001 |