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Table 1 Baseline characteristics

From: Gene expression profiles associated with acute myocardial infarction and risk of cardiovascular death

Baseline characteristics All subjects (N = 338) Discovery cohort (N = 175) Replication cohort (N = 163) AMI (N = 60) No AMI (N = 278) P-value
Age (years) 62 ± 11 67 ± 10 56 ± 10 65 ± 11 61 ± 11 0.014
Male gender (%) 218 (65) 112 (64) 106 (65) 47 (78) 171 (62) 0.015
Caucasian race (%) 331 (98) 170 (97) 163 (100) 58 (97) 273 (99) 0.19
Systolic blood pressure (mmHg) 138 ± 23 142 ± 23 133 ± 21 135 ± 23 138 ± 23 0.36
BMI (kg/m2) 30 ± 7 29 ± 6 31 ± 8 29.6 ± 6.8 30.2 ± 7.0 0.53
Serum creatinine (mg/dl) 1.3 ± 1.1 1.3 ± 1.4 1.2 ± 0.7 1.6 ± 2.2 1.2 ± 0.7 0.009
Acute MI (%) 60 (18) 37 (21) 23 (14) - - -
Old MI (%) 109 (32) 61 (35) 48 (30) 13 (22) 96 (35) 0.060
Current smoking (%) 73 (22) 34 (19) 39 (24) 8 (14) 65 (24) 0.09
Diabetes (%) 120 (36) 65 (37) 55 (34) 29 (48) 91 (33) 0.024
Hypertension (%) 258 (77) 142 (81) 116 (72) 46 (77) 212 (77) 0.98
Dyslipidemia (%) 263 (78) 133 (79) 102 (77) 47 (78) 216 (78) 0.95
Chronic heart failure (%) 76 (23) 41 (24) 35 (21) 15 (25) 61 (22) 0.61
LVEF (%) 54 ± 11 54 ± 11 54 ± 11 51 ± 11 54 ± 11 0.06
HDL (mg/dl) 43 ± 15 44 ± 14 41 ± 16 38 ± 14 44 ± 15 0.014
LDL (mg/dl) 92 ± 37 91 ± 36 94 ± 38 85 ± 33 94 ± 37 0.13
Triglyceride (mg/dl) 159 ± 115 150 ± 93 170 ± 137 154 ± 107 160 ± 117 0.73
Total cholesterol (mg/dl) 166 ± 45 164 ± 42 169 ± 48 153 ± 35 169 ± 47 0.02
History of CABG (%) 73 (21) 42 (24) 31 (19) 13 (22) 60 (22) 0.99
Gensini score 35 ± 54 38 ± 57 31 ± 55 48 ± 54 32 ± 54 0.046
Aspirin use (%) 83 131 (81) 131 (84) 48 (89) 214 (82) 0.2
Beta blocker use (%) 213 (67) 107 (67) 106 (67) 45 (82) 168 (64) 0.012
Clopidogrel use (%) 171 (55) 91 (56) 80 (53) 34 (64) 137 (53) 0.13
ACE-inh/ARB use (%) 192 (61) 100 (62) 92 (61) 35 (67) 157 (60) 0.35
Statin use (%) 244 (78) 129 (80) 115 (76) 44 (83) 200 (77) 0.33
>50% stenosis (in any major epicardial artery (%) 235 (70) 133 (76) 102 (64) 59 (93) 176 (64) <0.001
  1. P-value denotes differences between those with and without AMI. Abbreviations: ACE-inh/ARB angiotensin converting enzyme inhibitor or angiotensin receptor blockers, BMI body mass index, CABG coronary artery bypass graft, HDLhigh-density lipoprotein, LDLlow-density lipoprotein, LVEF left ventricular ejection fraction, MI myocardial infarction.