Genetics and genomics of Parkinson’s disease

Table 1 Genomic loci implicated in Parkinson’s disease by genome-wide association analyses

Gene	Chr	Associated SNP/locus	Genes within locus^a	Odds ratio [95% CI]	P-value
GBA	1q21	N370S	TRIM46, MUC1, MIR92B, THBS3, GBAP1-GBA-FAM189B, SCAMP3, CLK2, HCN3, PKLR	3.37 [2.67-4.29]	1.11E-24
SYT11/RAB25	1q21	chr1:154105678	MIR7851, UBQLN4, LAMTOR2-RAB25-MEX3A, LMNA	1.67 [1.41-1.98]	5.70E-09
PM20D1	1q32	rs11240572	NUCK1-RAB7L1-SLC41A1, PM20D1	0.74 [0.69-0.80]	1.01E-14
STK39	2q24	rs2102808	STK39	1.28 [1.19-1.38]	1.54E-11
MCCC1/LAMP3	3q27	rs11711441	MCCC1-LAMP3-MCF2L2	0.84 [0.80-0.89]	8.72E-12
BST1	4p15	rs4698412	FAM200B-BST1	0.87 [0.83-0.91]	2.28E-10
GAK/DGKQ	4p16	rs1564282	CPLX1-GAK-TMEM175-DGKQ-SLC26A1, IDUA, FGFRL1	1.29 [1.20-1.38]	6.54E-13
SNCA	4q21	rs356220	SNCA-MMRN1	1.30 [1.25-1.34]	3.06E-49
HLA-DRB5	6p21	rs2395163	HLA-DRB5-HLA-DRB1, HLA-DRB6	0.75 [0.68-0.84]	2.90E-07
GPNMB	7p15	rs156429	GPNMB-MALSU1-IGF2BP3	0.89 [0.86-0.93]	2.69E-10
LRRK2	12q12	rs34778348	SLC2A13-LRRK2-MUC19, CNTN1	2.23 [1.89-2.63]	2.97E-21
CCDC62/HIP1R	12q24	rs12817488	DENR-HIP1R-VPS37B, ABCB9, OGFOD2,	1.17 [1.09-1.25]	2.99E-06
MAPT/STH	17q21	H1H2, 900kb inversion	ARHGAP27, PLEKHM1, CRHR1, SPPL2C-MAPT-STH, KANSL1, LRRC37A, NSFP1, ARL17A/B	0.78 [0.75-0.80]	3.54E-52

Chr, chromosomal band; CI, confidence interval. ^aGenes within 100 kb of the most significantly associated SNP annotated from the UCSC genome browser (hg19). Odds ratios and P-values are the most significant findings from the PDGene database [150].

ISSN: 1756-994X