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Table 1 Characteristics of the samples used from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

From: A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

Factors   Methylation signature P value
   Positive Negative  
OCP use in the past Yes 72 60 0.604
  No 55 54  
Pregnancies <6 months Yes 32 35 0.387
  No 95 78  
Pregnancies >6 months Yes 109 102 0.439
  No 18 12  
Mother breast cancer Yes 14 11 0.833
  No 113 103  
Grandmother(s) breast cancer Yes 2 7 0.0887
  No 125 107  
Sister(s) breast cancer Yes 5 11 0.118
  No 122 103  
Aunt(s) breast cancer Yes 12 6 0.233
  No 115 108  
Any family member breast cancer Yes 29 32 0.376
  No 98 82  
Alcohol units per week Yes 78 68 1
  No 26 23  
Smoker Yes 41 37 0.89
  No 84 72  
  1. The samples were categorised according to their individual risk scores. These risk scores are the product of the methylation profile with the regression coefficients of the signature. The statistical significance was assessed by a two-sided, Fisher’s exact test. The missing values were excluded from the analysis.