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Table 1 Overview of different sets of diseases, drugs, and drug-disease pairs

From: Molecularly and clinically related drugs and diseases are enriched in phenotypically similar drug-disease pairs

 

Diseases

Drugs

Drug-disease pairs

Disease/drug-feature pairs

55,031

155,973

-

With phenotypic features

4,869

1,667

8,116,623

With molecular information linked to human PPI

642

939

602,838

Drug-ADR-disease pairs/with PPI

1,294/76

736/619

34,467/1,442

Indications/with PPI

532/57

786/212

2,637/311

Contraindications/with PPI

229/23

948/58

2,230/61

Clinical trials/with PPI

813/68

1,022/197

7,744/381

In phenotypic similarity network

2,565

957

7,368

In network, with MeSH disease level 1

1,648

-

-

In network, with ATC information

-

805

-

In network, with MeSH disease level 2/drug MoA

939

379

1,352

  1. ADR, adverse drug reaction MoA, mechanisms of action.