Muscle specific pathway-level comparisons between the guinea pig model and a clinical COPD study (GSE27536). The figure displays the result of the sensitivity and specificity analysis for each of the six experimental conditions at the KEGG pathway level, where ‘true response’ is defined by the 19 enriched KEGG pathways in the vastus lateralis of muscle-wasted COPD patients when compared to matched healthy controls. (A) Plot where the x-axis represents the experimental conditions in the guinea pig model. The two y-axes represent (1) the true positive rate as a fraction, and (2) the actual number of overlapping pathways with the human COPD cohort. In this panel specificity and sensitivity is computed without considering the direction of change in expression (up- and downregulation). (B) The equivalent of the plot in (A) where specificity and sensitivity is computed taking into consideration the direction of change. The grey-coloured crosses indicate the sensitivity values from the undirected approach presented in (A). (C) represents the specific pathways regulated in the guinea pig model (columns 2 to 4) when contrasted against COPD patients with a muscle-wasting phenotype (column 1). Green-coloured cells indicate enrichment among downregulated transcripts; red-coloured cells indicate enrichment among the upregulated transcripts; and yellow-coloured cells indicate enrichment for transcripts enriched in both directions.