Table 5 Large blocks of aberrant methylation arise early in carcinogenesis and develop along with cancer
From: Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
| Â | Blocks (n) | Total Mb inside blocks | Intersection with colon blocks (%) | 25%length quartile (Mb) | 50%length quartile (Mb) | 75%length quartile (Mb) | Median diff value | Hypo. (%) |
|---|---|---|---|---|---|---|---|---|
Benign | 142 | 25.3 | 90 | 0.098 | 0.14 | 0.21 | −0.047 | 58 |
Follicular adenoma | 270 | 50.17 | 90 | 0.08825 | 0.15 | 0.24 | −0.048 | 77 |
Minimally invasive carcinoma | 297 | 56.3 | 79 | 0.098 | 0.15 | 0.24 | −0.054 | 94 |
Capsular invasive carcinoma | 599 | 109.37 | 80 | 0.09 | 0.15 | 0.23 | −0.074 | 90 |
Vascular invasive carcinoma | 376 | 67.85 | 82 | 0.091 | 0.15 | 0.24 | −0.053 | 78 |
Metastatic cancer | 729 | 125.42 | 67 | 0.088 | 0.14 | 0.22 | −0.066 | 92 |