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Table 5 Large blocks of aberrant methylation arise early in carcinogenesis and develop along with cancer

From: Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

  Blocks (n) Total Mb inside blocks Intersection with colon blocks (%) 25%length quartile (Mb) 50%length quartile (Mb) 75%length quartile (Mb) Median diff value Hypo. (%)
Benign 142 25.3 90 0.098 0.14 0.21 −0.047 58
Follicular adenoma 270 50.17 90 0.08825 0.15 0.24 −0.048 77
Minimally invasive carcinoma 297 56.3 79 0.098 0.15 0.24 −0.054 94
Capsular invasive carcinoma 599 109.37 80 0.09 0.15 0.23 −0.074 90
Vascular invasive carcinoma 376 67.85 82 0.091 0.15 0.24 −0.053 78
Metastatic cancer 729 125.42 67 0.088 0.14 0.22 −0.066 92
  1. Columns are as in Table3. As in Table3, P values were all below 0.001.