Figure 6

The power of the patient-survival gene network in prognosis and druggability. (A) Prognostic power. The boxplots display the distribution of Cox HR for: the randomly chosen 42 genes (as a naive method; in red), the 42 individual genes in the network (as identified by dnet; in green), and the genes in the network used in combination (in blue). Genes in the network used in combination yields an average of a 10-fold increase in Cox HR over using those genes individually (66.1 versus 6.2), which equates to a 100-fold gain in Cox HR using genes naively (66.1 versus 0.6). (B) Druggable power. The table lists significant enrichments of druggable gene categories and their annotated genes.