Evolutionary age of genes in the survival network. This is a heatmap of the mutation frequency of genes (in rows) versus tumour types (in columns). The tumour types are ordered based on a neighbour-joining tree (built from the mutation frequency matrix). The evolutionary history of genes is based on species tree of life (sTOL ). The left panel indicates the ancestor in which genes first appeared. Ancestor enrichment analysis shows that these survival genes contain a significantly higher number of genes first created at Metazoa, Deuterostomia and Chordata (framed in blue; FDR <0.05). Indicated beside the gene symbols are their Cox P values: *<0.05; **<0.01 and ***<0.005. Abbreviations for tumour types are the same as described in Figure5.