Genes first appearing in Deuterostomia mutate more ubiquitously and tend to be hubs. (A) Boxplot of genes in the survival network. Dots represent genes, color-coded according to their Cox P values. These genes are grouped according to ancestor in which they first appeared (x-axis). Cross-tumour mutation ubiquity (y-axis) measures how ubiquitous the mutation rate of a gene is in different tumour types. (B) Visualisation of the survival network with nodes/genes color-coded by mutation ubiquity. Also indicated are genes first appeared in Deuterostomia. The bottom-left inset shows the differential distributions of node degrees for genes first appeared in Deuterostomia against in our other ancestors.