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Figure 1 | Genome Medicine

Figure 1

From: VISPA: a computational pipeline for the identification and analysis of genomic vector integration sites

Figure 1

IS analysis procedure for the Roche 454 sequencing platform. (A) DNA fragments containing the vector-cellular genome junctions are retrieved and amplified from vector marked genomic DNA by LAM-PCR. (B) LAM-PCR products are processed by the NGS platform, yielding sequencing reads that have to be processed in silico. (C) Bioinformatics pipeline, from FASTA extraction to IS identification and annotation.

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