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Figure 2 | Genome Medicine

Figure 2

From: Whole-genome haplotyping approaches and genomic medicine

Figure 2

The properties of phasing methods. The level of confidence in phasing and the achievable range of phased sequence length both vary depending on the method used. Molecular methods provide direct observations from single molecules and therefore the level of confidence in the results is high. The phased sequence length that can be achieved by these methods has a wide range, which depends on the method employed. Molecular observations can be assembled into haplotypes (dashed arrows), adding moderately to the range of phased sequence length, and potentially introducing inference error. Genetic analyses infer phase by leveraging the property of Mendelian segregation and can phase entire chromosomes. Population inference methods are probabilistic and limited to the generation of short-range haplotype blocks.

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