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Table 2 Logistic regression analysis for associations with tumor response, with and without adjustment for the proliferation metagene and subtype

From: Dual roles for immune metagenes in breast cancer prognosis and therapy prediction

Variable Odds ratio P -value b Adjusted odds ratio c P -value
(95% CI) a (95% CI)
B/P 1.60 (1.35-1.89) <0.0001 1.41 (1.18-1.69) 0.0002
T/NK 1.59 (1.32-2.05) 0.0004 1.66 (1.23-2.25) 0.001
M/D 1.69 (1.35-2.11) <0.0001 1.66 (1.28-2.15) 0.0001
P 2.54 (1.90-3.41) <0.0001 - -
Subtyped - <0.0001 - -
  1. B/P = B cells/plasma B cells; CL, Clauin-Low subtype; CI = confidence interval; LumA = Luminal A; LumB = Luminal B; M/D = monocyte/dendritic cell population; T/NK = T cell/natural killer cell-specific population; P = proliferation.
  2. a95% confidence interval. bLikelihood ratio test P-value. cAdjustment for P metagene as a continuous variable and subtype as a categorical variable. dOdds ratios (versus normal subtype) and 95% CI and P-value for each subtype are: basal-like (1.33; 0.43-4.10; 0.0006), CL (1.12; 0.32-3.87; 0.13), HER2-enriched (1.08; 0.33-3.56; 0.10), LumA (0.18, 0.06-0.60; <0.0001) and LumB (0.55; 0.17-1.75; 0.16).