Dual roles for immune metagenes in breast cancer prognosis and therapy prediction

Table 2 Logistic regression analysis for associations with tumor response, with and without adjustment for the proliferation metagene and subtype

Variable	Odds ratio	P -value ^b	Adjusted odds ratio ^c	P -value
Variable	(95% CI) ^a	P -value ^b	(95% CI)	P -value
B/P	1.60 (1.35-1.89)	<0.0001	1.41 (1.18-1.69)	0.0002
T/NK	1.59 (1.32-2.05)	0.0004	1.66 (1.23-2.25)	0.001
M/D	1.69 (1.35-2.11)	<0.0001	1.66 (1.28-2.15)	0.0001
P	2.54 (1.90-3.41)	<0.0001	-	-
Subtype^d	-	<0.0001	-	-

B/P = B cells/plasma B cells; CL, Clauin-Low subtype; CI = confidence interval; LumA = Luminal A; LumB = Luminal B; M/D = monocyte/dendritic cell population; T/NK = T cell/natural killer cell-specific population; P = proliferation.
^a95% confidence interval. ^bLikelihood ratio test P-value. ^cAdjustment for P metagene as a continuous variable and subtype as a categorical variable. ^dOdds ratios (versus normal subtype) and 95% CI and P-value for each subtype are: basal-like (1.33; 0.43-4.10; 0.0006), CL (1.12; 0.32-3.87; 0.13), HER2-enriched (1.08; 0.33-3.56; 0.10), LumA (0.18, 0.06-0.60; <0.0001) and LumB (0.55; 0.17-1.75; 0.16).

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